Clinicopathological analysis and risk factors of advanced colorectal neoplasms incidentally detected by 18F-FDG PET-CT.

Chung, Seung Min; Kim, Kyeong Ok; Cho, Ihn Ho; Kim, Tae Nyeun
European journal of gastroenterology & hepatology
2017Apr ; 29 ( 4 ) :407-413.
저자 상세정보
Chung, Seung Min -
Kim, Kyeong Ok -
Cho, Ihn Ho -
Kim, Tae Nyeun -
ABSTRACT
BACKGROUND: As the clinical use of fluorine-18-fluorodeoxyglucose PET-computed tomography (F-FDG PET-CT) has increased, the incidental finding of F-FDG uptake with subsequent diagnosis of advanced neoplasm at colorectum has increased. The aim of this study is to analyze the characteristics and risk factors of advanced colorectal neoplasm incidentally detected by F-FDG PET-CT. PATIENTS AND

METHODS: Patients who underwent colonoscopy because of an incidental finding of F-FDG uptake at the colorectum from January 2006 to January 2015 at Yeungnam University Hospital were reviewed retrospectively. Advanced neoplasm was defined as adenoma of at least 10?mm, adenoma with serrated or villous component, high-grade dysplasia, and adenocarcinoma.

RESULTS: Of the 19?798 candidates, 180 patients with incidental colorectal F-FDG uptake were included in this study. The indications of PET-CT were metastasis work-up, health screening, and others. The male to female ratio was 1.6?:?1 and the mean age was 62.7짹11.4 years. A total of 156 lesions were detected in the colorectum and 86 (47.8%) were diagnosed as advanced neoplasms. Of the 86 patients with advanced neoplasms, 34 (39.5%) underwent an operation, 34 (39.5%) underwent endoscopic resection, and 18 (20.9%) underwent chemotherapy or conservative treatments. In univariate analysis, age of 62.5 years or older, carcinoembryonic antigen (CEA) of at least 3.4?ng/ml, maximum standardized uptake value (SUVmax) of at least 8.0, hypertension, F-FDG uptake on the rectosigmoid, and PET-CT for metastasis work-up showed a significant association with advanced neoplasm. In multivariate analysis, CEA (P=0.028), SUVmax (P<0.001) and an indication of PET-CT for metastasis work-up (P=0.008) were independent predictors of advanced neoplasm. CONCLUSION: Colonoscopy should be recommended in case of F-FDG uptake at the colorectum, particularly in patients with CEA of at least 3.4?ng/ml, SUVmax of at least 8.0, or metastasis work-up of malignancy.
na
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Colonoscopy should be recommended in case of 18F-FDG uptake at the colorectum, particularly in patients with CEA of at least 3.4ng/ml, SUVmax of at least 8.0, or metastasis work-up of malignancy.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1097/MEG.0000000000000808
KCD코드
ICD 03
건강보험코드