Kim, Hyeong Nyeon; Hur, Mina; Kim, Hanah; Ji, Misuk; Moon, Hee-Won; Yun, Yeo-Min; Lee, Mark Hong
Annals of clinical and laboratory science
2016Jul ; 46 ( 4 ) :435-8.
PMID : 27466307
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Kim, Hyeong Nyeon -
Hur, Mina -
Kim, Hanah -
Ji, Misuk -
Moon, Hee-Won -
Yun, Yeo-Min -
Lee, Mark Hong -
ABSTRACT
Mixed phenotype acute leukemia (MPAL) includes biphenotypic leukemia, bilineal leukemia, or its combination by the 2008 WHO classification. A few cases of combined biphenotypic/bilineal MPAL have been reported so far; they all had biphenotypic expressions in only one of the two distinct leukemic populations. A 43-year-old female presented with leukocytosis and bicytopenia. Her complete blood counts were: hemoglobin, 6.9 g/dL; white blood cells, 62.8×10(9)/L; and platelets, 83×10(9)/L. Neither lymphadenopathy nor organomegaly was observed. Blasts and promonocytes/monoblasts were increased in her peripheral blood (42%) and bone marrow (60.1%). Flow cytometric analysis revealed two distinct populations of leukemic cells, which expressed CD11c, CD19, and cytoplasmic CD79a in common. Additionally, the first population expressed CD10 and CD117 (B/myeloid), and the second one expressed CD14 and CD20 (B/monocytic). She had a karyotype of 46,XX,inv(9)(p12q13),t(9;22)(q34;q11.2)[20] and BCR/ABL1 rearrangement. To the best of our knowledge, this is the first reported case of biphenotypic/bilineal MPAL with B/myeloid and B/monocytic expressions. CI - ??2016 by the Association of Clinical Scientists, Inc.
Mixed phenotype acute leukemia, Biphenotype, Bilineage
MESH
Adult, Chromosomes, Human, Pair 22/*genetics, Chromosomes, Human, Pair 9/*genetics, Female, Flow Cytometry, Fusion Proteins, bcr-abl/*genetics, Humans, Leukemia/*genetics/*pathology, Monocytes/*pathology, Myeloid Cells/*pathology, Phenotype, *Translocation, Genetic
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