Ahn, Hongkeun; Kwon, Ji Eun; Sohn, Seong-Wook; Kwon, Ji-Hyun; Kim, Joo Sung; Yoon, Sung-Soo; Kang, Hye-Ryun; Hong, Kyoung Sup
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
2016Jun ; 32 ( Suppl 1 ) :96-99.
PMID : 27408366
저자 상세정보
Ahn, Hongkeun -
Kwon, Ji Eun -
Sohn, Seong-Wook -
Kwon, Ji-Hyun -
Kim, Joo Sung -
Yoon, Sung-Soo -
Kang, Hye-Ryun -
Hong, Kyoung Sup -
ABSTRACT
Dasatinib is an effective treatment option for patients diagnosed with Philadelphia chromosome positive chronic myeloid leukemia and who are non-responsive or intolerant to imatinib treatment. Dasatinib, however, is associated with various adverse effects and on rare occasions, may cause hemorrhagic colitis. We report the case of a 68-year-old male patient with dasatinib-induced hemorrhagic colitis, the first such case in Korea. Endoscopic biopsy of the transverse colon demonstrated non-specific inflammatory changes only. Cessation of dasatinib led to the resolution of symptoms, while reintroduction of the therapy led to the recurrence of his bloody diarrhea. To clarify the association between dasatinib and hemorrhagic colitis, the lymphocyte transformation test (LTT) was performed. The LTT result sustained a relatively high proliferation activity in the affected patient compared with almost no proliferation activity in normal control.
Adverse drug reaction; Dasatinib; Drug hypersensitivity; Hemorrhagic colitis
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