Ji, Misuk; Hur, Mina; Kim, Hyeong Nyeon; Moon, Hee-Won; Yun, Yeo-Min; Kim, Sung-Yong; Han, Sung-Hee
Annals of clinical and laboratory science
2016May ; 46 ( 3 ) :308-11.
PMID : 27312558
ÀúÀÚ »ó¼¼Á¤º¸
Ji, Misuk - Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Hur, Mina - Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea dearmina@hanmail.net.
Kim, Hyeong Nyeon - Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Moon, Hee-Won - Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Yun, Yeo-Min - Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Kim, Sung-Yong - Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Han, Sung-Hee - Seoul Clinical Laboratories, Seoul Medical Science Institute, Yongin, Korea.
ABSTRACT
At diagnosis, fewer than 10% of chronic myelogenous leukemia (CML) patients have additional cytogenetic abnormalities (ACAs), which are frequently found in transformation to blast crisis. We report a case of CML-chronic phase (CML-CP) that showed t(1;15) at diagnosis. A 64-year-old man presented with sustained leukocytosis and thrombocytosis. His bone marrow (BM) was hypercellular with 2.5% blasts and BCR-ABL1 rearrangement. The karyotype in the BM was 46,XY,t(1;15)(q32;p13),t(9;22)(q34;q11.2)[20], while the karyotype in the peripheral blood was 46,XY[20]. This is the first report on the presence of t(1;15) at diagnosis of CML-CP, and its clinical significance remains unclear. CI - ??2016 by the Association of Clinical Scientists, Inc.
keyword
additional cytogenetic abnormality; chronic myelogenous leukemia; chronic phase; diagnosis; t(1; 15)
¸µÅ©