Effects of aerobic exercise training on peripheral brain-derived neurotrophic factor and eotaxin-1 levels in obese young men.

Cho, Su Youn; Roh, Hee Tae
Journal of physical therapy science
2016Apr ; 28 ( 4 ) :1355-8.
PMID : 27190482
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Cho, Su Youn - Exercise Physiology Laboratory, Department of Physical Education, Yonsei University, Republic of Korea.
Roh, Hee Tae - Department of Physical Education, College of Arts and Physical Education, Dong-A University, Republic of Korea.
ABSTRACT
[Purpose] The aim of the present study was to investigate the effects of aerobic exercise training on the levels of peripheral brain-derived neurotrophic factor and eotaxin-1 in obese young men. [Subjects and Methods] The subjects included sixteen obese young men with a body mass index greater than 25?kg/m(2). They were randomly divided between control and exercise groups (n = 8 in each group). The exercise group performed treadmill exercise for 40?min, 3 times a week for 8 weeks at the intensity of 70% heart rate reserve. Blood collection was performed to examine the levels of serum glucose, plasma malonaldehyde, serum brain-derived neurotrophic factor, and plasma eotaxin-1 before and after the intervention (aerobic exercise training). [Results] Following the intervention, serum BDNF levels were significantly higher, while serum glucose, plasma MDA, and plasma eotaxin-1 levels were significantly lower than those prior to the intervention in the exercise group. [Conclusion] Aerobic exercise training can induce neurogenesis in obese individuals by increasing the levels of brain-derived neurotrophic factor and reducing the levels of eotaxin-1. Alleviation of oxidative stress is possibly responsible for such changes.
keyword
Aerobic exercise; BDNF; CCL11
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Following the intervention, BMI, fat mass, body fat, waist circumference, serum glucose levels, plasma MDA levels, and plasma CCL11 levels were significantly lower.
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DOI
10.1589/jpts.28.1355
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ICD 03
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