Kong, Moonkyoo; Hwang, Deok-Sang; Lee, Jee Young; Yoon, Seong Woo
Evidence-based complementary and alternative medicine : eCAM
2016NA ; 2016 ( 1 ) :9481413.
PMID : 27066103
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Kong, Moonkyoo - Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, 23 Kyungheedae-gil, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
Hwang, Deok-Sang - Department of Korean Medicine Obstetrics & Gynecology, Kyung Hee University Medical Center, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-gil, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
Lee, Jee Young - Department of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-gil, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
Yoon, Seong Woo - Department of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-gil, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
ABSTRACT
Purpose. This study was performed to evaluate the efficacy and safety of Jaungo in preventing radiation dermatitis in patients with breast cancer. Methods. Thirty patients were prospectively enrolled and randomly assigned to receive Jaungo or general supportive skin care. Radiation dermatitis and pain were examined at daily intervals from the start of radiotherapy until 4 weeks after its completion. The primary endpoint of this study was the incidence of radiation dermatitis. The secondary endpoints were time to onset of radiation dermatitis, duration of radiation dermatitis, and maximum pain score. Results. Jaungo reduced the incidence of grade ?? (46.7% versus 78.6%) and grade 3 radiation dermatitis (20.0% versus 50.0%) in comparison with general supportive skin care. Jaungo also delayed the onset of grade 2 dermatitis (35 days versus 30 days). In terms of time to onset of grade 3 dermatitis, duration of dermatitis, and maximum pain score, Jaungo showed results comparable to those achieved with general supportive skin care. No patients experienced adverse effects caused by Jaungo administration. Conclusions. Jaungo minimized radiation dermatitis in patients with breast cancer without causing adverse effects. Further randomized studies with a larger sample size are required to assess clinical use of Jaungo.
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