Berndt, Sonja I; Camp, Nicola J; Skibola, Christine F; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; Nieters, Alexandra; Kelly, Rachel S; Smedby, Karin E; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S; Lan, Qing; Teras, Lauren R; Machado, Moara; Yeager, Meredith; Brooks-Wilson, Angela R; Hartge, Patricia; Purdue, Mark P; Birmann, Brenda M; Vajdic, Claire M; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G; Shanafelt, Tait D; Novak, Anne J; Kay, Neil E; Liebow, Mark; Cunningham, Julie M; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A; Diver, W Ryan; Link, Brian K; Weiner, George J; Conde, Lucia; Bracci, Paige M; Riby, Jacques; Arnett, Donna K; Zhi, Degui; Leach, Justin M; Holly, Elizabeth A; Jackson, Rebecca D; Tinker, Lesley F; Benavente, Yolanda; Sala, Nuria; Casabonne, Delphine; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G; Achenbach, Sara J; Vachon, Celine M; Goldin, Lynn R; Strom, Sara S; Leis, Jose F; Weinberg, J Brice; Caporaso, Neil E; Norman, Aaron D; De Roos, Anneclaire J; Morton, Lindsay M; Severson, Richard K; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque, Maria-Dolores; Vermeulen, Roel C H; Travis, Ruth C; Southey, Melissa C; Milne, Roger L; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Clavel, Jacqueline; Zheng, Tongzhang; Holford, Theodore R; Villano, Danylo J; Maria, Ann; Spinelli, John J; Gascoyne, Randy D; Connors, Joseph M; Bertrand, Kimberly A; Giovannucci, Edward; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Grazia; Ferri, Giovanni M; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nilanjan; North, Kari E; Snowden, John A; Wright, Josh; Fraumeni, Joseph F; Offit, Kenneth; Wu, Xifeng; de Sanjose, Silvia; Cerhan, James R; Chanock, Stephen J; Rothman, Nathaniel; Slager, Susan L
Nature communications
2016NA ; 7 ( 3 ) :10933.
PMID : 26956414
ÀúÀÚ »ó¼¼Á¤º¸
Berndt, Sonja I -
Camp, Nicola J -
Skibola, Christine F -
Vijai, Joseph -
Wang, Zhaoming -
Gu, Jian -
Nieters, Alexandra -
Kelly, Rachel S -
Smedby, Karin E -
Monnereau, Alain -
Cozen, Wendy -
Cox, Angela -
Wang, Sophia S -
Lan, Qing -
Teras, Lauren R -
Machado, Moara -
Yeager, Meredith -
Brooks-Wilson, Angela R -
Hartge, Patricia -
Purdue, Mark P -
Birmann, Brenda M -
Vajdic, Claire M -
Cocco, Pierluigi -
Zhang, Yawei -
Giles, Graham G -
Zeleniuch-Jacquotte, Anne -
Lawrence, Charles -
Montalvan, Rebecca -
Burdett, Laurie -
Hutchinson, Amy -
Ye, Yuanqing -
Call, Timothy G -
Shanafelt, Tait D -
Novak, Anne J -
Kay, Neil E -
Liebow, Mark -
Cunningham, Julie M -
Allmer, Cristine -
Hjalgrim, Henrik -
Adami, Hans-Olov -
Melbye, Mads -
Glimelius, Bengt -
Chang, Ellen T -
Glenn, Martha -
Curtin, Karen -
Cannon-Albright, Lisa A -
Diver, W Ryan -
Link, Brian K -
Weiner, George J -
Conde, Lucia -
Bracci, Paige M -
Riby, Jacques -
Arnett, Donna K -
Zhi, Degui -
Leach, Justin M -
Holly, Elizabeth A -
Jackson, Rebecca D -
Tinker, Lesley F -
Benavente, Yolanda -
Sala, Nuria -
Casabonne, Delphine -
Becker, Nikolaus -
Boffetta, Paolo -
Brennan, Paul -
Foretova, Lenka -
Maynadie, Marc -
McKay, James -
Staines, Anthony -
Chaffee, Kari G -
Achenbach, Sara J -
Vachon, Celine M -
Goldin, Lynn R -
Strom, Sara S -
Leis, Jose F -
Weinberg, J Brice -
Caporaso, Neil E -
Norman, Aaron D -
De Roos, Anneclaire J -
Morton, Lindsay M -
Severson, Richard K -
Riboli, Elio -
Vineis, Paolo -
Kaaks, Rudolph -
Masala, Giovanna -
Weiderpass, Elisabete -
Chirlaque, Maria-Dolores -
Vermeulen, Roel C H -
Travis, Ruth C -
Southey, Melissa C -
Milne, Roger L -
Albanes, Demetrius -
Virtamo, Jarmo -
Weinstein, Stephanie -
Clavel, Jacqueline -
Zheng, Tongzhang -
Holford, Theodore R -
Villano, Danylo J -
Maria, Ann -
Spinelli, John J -
Gascoyne, Randy D -
Connors, Joseph M -
Bertrand, Kimberly A -
Giovannucci, Edward -
Kraft, Peter -
Kricker, Anne -
Turner, Jenny -
Ennas, Maria Grazia -
Ferri, Giovanni M -
Miligi, Lucia -
Liang, Liming -
Ma, Baoshan -
Huang, Jinyan -
Crouch, Simon -
Park, Ju-Hyun -
Chatterjee, Nilanjan -
North, Kari E -
Snowden, John A -
Wright, Josh -
Fraumeni, Joseph F -
Offit, Kenneth -
Wu, Xifeng -
de Sanjose, Silvia -
Cerhan, James R -
Chanock, Stephen J -
Rothman, Nathaniel -
Slager, Susan L -
ABSTRACT
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
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