Kim, Su Mi; Cho, Juhee; Kang, Danbee; Oh, Seung Jong; Kim, Ae Ran; Sohn, Tae Sung; Noh, Jae Hyoung; Kim, Sung
Annals of surgery
2016Jun ; 263 ( 6 ) :1079-84.
PMID : 26727095
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Kim, Su Mi -
Cho, Juhee -
Kang, Danbee -
Oh, Seung Jong -
Kim, Ae Ran -
Sohn, Tae Sung -
Noh, Jae Hyoung -
Kim, Sung -
ABSTRACT
OBJECTIVE: To compare the postoperative quality of life of vagus nerve preserving distal gastrectomy (VPG) vs conventional distal gastrectomy (CG) in patients with early-stage gastric cancer. DESIGN: Randomized controlled clinical trial. SETTING: Large tertiary comprehensive cancer center in Korea. PARTICIPANTS: One hundred sixty-three patients with early gastric cancer 18 years of age or older expected to undergo curative gastric resection. INTERVENTION: Patients were randomized 1:1 to VPG (n = 85) or CG (n = 78). MAIN OUTCOME MEASURES: European Organization for Research and Treatment of Cancer (EORTC) gastric module (STO22).
RESULTS: Patients assigned to VPG showed less diarrhea 3 and 12 months after surgery (P = 0.040 and 0.048, respectively) and less appetite loss at 12 months (P = 0.011) compared with those assigned to CG. In both groups, fatigue, anxiety, eating restriction, and body image deteriorated at 3 months after surgery and did not regain baseline levels 12 months after surgery. There were no significant differences between the 2 groups in cancer recurrence and death over 5 years of follow-up.
CONCLUSIONS: Early gastric cancer patients undergoing VPG reported significantly less diarrhea and appetite loss at 12 months postsurgery compared with those undergoing CG, with no differences in long-term clinical outcomes. VPG may improve the quality of life after gastrectomy in early gastric cancer patients compared with CG.
Appetite loss, diarrhea, gasterctomy, gastric cancer, vagus nerve
MESH
Demography, Diarrhea/epidemiology, Female, Gastrectomy/*methods, Humans, Male, Middle Aged, Neoplasm Staging, Postoperative Complications/epidemiology, *Quality of Life, Republic of Korea/epidemiology, Stomach Neoplasms/pathology/*surgery, Treatment Outcome, Vagus Nerve/*surgery
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