Kim, Bo Wook; Cho, Hanbyoul; Choi, Chel Hun; Ylaya, Kris; Chung, Joon-Yong; Kim, Jae-Hoon; Hewitt, Stephen M
BMC cancer
2015NA ; 15 ( 48 ) :1015.
PMID : 26706028
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Kim, Bo Wook -
Cho, Hanbyoul -
Choi, Chel Hun -
Ylaya, Kris -
Chung, Joon-Yong -
Kim, Jae-Hoon -
Hewitt, Stephen M -
ABSTRACT
BACKGROUND: Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. Cancer stem cell markers including OCT4 and SOX2 have been found in various solid tumors. Here, we investigate the expression and clinical significance of OCT4 and SOX2 in cervical cancer.
METHODS: To define the clinical significance of OCT4 and SOX2 expression, we performed immunohistochemistry for OCT4 and SOX2 on 305 normal cervical epithelium samples, 289 cervical intraepithelial neoplasia samples, and 161 cervical cancer cases and compared the data with clinicopathologic factors, including survival rates of patients with cervical cancer.
RESULTS: OCT4 and SOX2 expression was higher in cervical cancer than normal cervix (both p?
CONCLUSIONS: These results suggest that OCT4 overexpression and loss of SOX2 expression are strongly associated with poor prognosis in patients with cervical cancer.
Neoplastic stem cells, OCT4, SOX2, Prognosis, Survival, Uterine cervical neoplasms
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