Sarker, Azmal; Im, Hyung-Jun; Cheon, Gi Jeong; Chung, Hyun Hoon; Kang, Keon Wook; Chung, June-Key; Kim, E Edmund; Lee, Dong Soo
Clinical nuclear medicine
2016Jan ; 41 ( 1 ) :34-40.
PMID : 26505856
ÀúÀÚ »ó¼¼Á¤º¸
Sarker, Azmal -
Im, Hyung-Jun -
Cheon, Gi Jeong -
Chung, Hyun Hoon -
Kang, Keon Wook -
Chung, June-Key -
Kim, E Edmund -
Lee, Dong Soo -
ABSTRACT
PURPOSE: We conducted a meta-analysis to evaluate the prognostic value of the SUVmax measured in pretreatment primary lesions and metastatic lymph nodes (LNs) on 18F-FDG PET scans in patients with uterine cervical cancer.
METHODS: A systematic search of EMBASE and MEDLINE was performed using the keywords "positron emission tomography (PET)," "uterine cervical cancer," and "prognosis." Event-free survival and overall survival were evaluated as outcomes. The impact of SUVmax on survival was measured by the effect size of the hazard ratio (HR).
RESULTS: Fourteen eligible studies including 1150 patients were analyzed. Patients with a high primary SUVmax showed a worse prognosis, with an HR of 2.66 (95% confidence interval [CI], 1.90-3.74; P < 0.00001) for adverse events and an HR of 2.45 (95% CI, 1.74-3.45; P < 0.00001) for death. Patients with high SUVmax in metastatic pelvic LN (PLN) showed a worse prognosis, with an HR of 2.92 (95% CI, 1.94-4.39; P < 0.00001) for adverse events and an HR of 2.66 (95% CI, 1.60-4.43; P = 0.0002) for SUVmax in PLN for death. In addition, high SUVmax in metastatic para-aortic LN was associated with a worse prognosis, with an HR of 4.41 (95% CI, 2.32-8.38; P < 0.00001) for death.
CONCLUSIONS: Patients with uterine cervical cancer and a high SUVmax primary lesion, PLN, or para-aortic LN are at higher risk of adverse events or death.
FDG PET, prognosis, SUVmax, uterine cervical cancer
¸µÅ©