Liu, Yan; Park, Ji-Eun; Shin, Kyung-Min; Lee, Minhee; Jung, Hee Jung; Kim, Ae-Ran; Jung, So-Young; Yoo, Ho Ryong; Sang, Kwon O; Choi, Sun-Mi
Complementary therapies in medicine
2015Oct ; 23 ( 5 ) :658-65.
PMID : 26365445
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Liu, Yan -
Park, Ji-Eun -
Shin, Kyung-Min -
Lee, Minhee -
Jung, Hee Jung -
Kim, Ae-Ran -
Jung, So-Young -
Yoo, Ho Ryong -
Sang, Kwon O -
Choi, Sun-Mi -
ABSTRACT
OBJECTIVES: To preliminarily assess the effects of acupuncture on prehypertension and stage I hypertension, and to provide data for further research. DESIGN: A randomized, controlled, assessor-blinded study with an 8-week intervention period and a 4-week follow-up. INTERVENTIONS: Participants were patients with systolic blood pressure (SBP) of 120-159mmHg or diastolic blood pressure (DBP) of 80-99mmHg.Thirty participants were allocated to acupuncture group or untreated control group at a 1:1 ratio. The acupuncture group received standard acupuncture twice weekly for 8 weeks, and was followed-up for 4 weeks after treatment; the control group did not receive any type of anti-hypertensive treatment for 12 weeks. MAIN OUTCOME MEASURES: Primary outcome measure was SBP and DBP at post-treatment. The secondary outcomes were SBP and DBP at follow-up; Euro Quality of life (EQ-5D), heart rate variability (HRV), body mass index (BMI), and blood lipid profile.
RESULTS: DBP (-5.7mmHg; P=0.025), but not SBP (-6.0mmHg; P=0.123), was significantly different between groups at post-treatment. Both DBP (-7.8mmHg; P=0.004) and SBP (-8.6mmHg; P=0.031) were significantly different at follow-up. Among the HRV indices, only high frequency power was significantly different between groups at weeks 4 and 8 (P=0.047 and P=0.030, respectively). There were no differences between groups in EQ-5D, BMI or lipid profile. CONCLUSION: The results of this study show that acupuncture might lower blood pressure in prehypertension and stage I hypertension, and further RCT need 97 participants in each group. The effect of acupuncture on prehypertension and mild hypertension should be confirmed in larger studies. TRIAL REGISTRATION: KCT0000496. CI - Copyright ??2015 Z. Published by Elsevier Ltd.. All rights reserved.
keyword
Acupuncture; Blood pressure; Heart rate variability; Prehypertension; Stage I hypertension
MESH
Acupuncture Therapy/*methods, Adult, Aged, Blood Pressure/*physiology, Female, Heart Rate/physiology, Humans, Lipids/blood, Male, Middle Aged, Pilot Projects, Prehypertension/physiopathology/*therapy, Young Adult
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