Deandrea, Maurilio; Sung, Jin Yong; Limone, Paolo; Mormile, Alberto; Garino, Francesca; Ragazzoni, Federico; Kim, Kyu Sun; Lee, Ducky; Baek, Jung Hwan
Thyroid : official journal of the American Thyroid Association
2015Aug ; 25 ( 8 ) :890-6.
PMID : 26061686
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Deandrea, Maurilio - 1 Endocrinology, Diabetes, and Metabolism Unit, A.O. Ordine Mauriziano di Torino, "Umberto I" Hospital , Turin, Italy .
Sung, Jin Yong - 2 Department of Radiology, Thyroid Center, Daerim St. Mary's Hospital , Seoul, Korea.
Limone, Paolo - 1 Endocrinology, Diabetes, and Metabolism Unit, A.O. Ordine Mauriziano di Torino, "Umberto I" Hospital , Turin, Italy .
Mormile, Alberto - 1 Endocrinology, Diabetes, and Metabolism Unit, A.O. Ordine Mauriziano di Torino, "Umberto I" Hospital , Turin, Italy .
Garino, Francesca - 1 Endocrinology, Diabetes, and Metabolism Unit, A.O. Ordine Mauriziano di Torino, "Umberto I" Hospital , Turin, Italy .
Ragazzoni, Federico - 1 Endocrinology, Diabetes, and Metabolism Unit, A.O. Ordine Mauriziano di Torino, "Umberto I" Hospital , Turin, Italy .
Kim, Kyu Sun - 2 Department of Radiology, Thyroid Center, Daerim St. Mary's Hospital , Seoul, Korea.
Lee, Ducky - 3 Department of Internal Medicine, Thyroid Center, Daerim St. Mary's Hospital , Seoul, Korea.
Baek, Jung Hwan - 4 Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine , Asan Medical Center, Seoul, Korea.
ABSTRACT
BACKGROUND: Percutaneous radiofrequency thermal ablation (RFA) has been reported as an effective tool for the management of benign thyroid nodules (BTN). However, large, randomized controlled trials (RCTs) are lacking. OBJECTIVE: The aims of this study were to assess the volume reduction of BTN after a single RFA performed using the moving-shot technique and to compare the volume reduction obtained in patients treated in two centers with different experience of the moving-shot technique. METHOD: This study was an international prospective RCT. It was carried out at the Mauriziano Hospital (Turin, Italy) and the Asan Medical Center (Seoul, Korea). Eighty patients harboring solid, compressive, nonfunctioning BTN (volume 10-20?mL) were enrolled. Twenty patients in each country were treated by RFA using a 18-Gauge internally cooled electrode (group A); 20 nontreated patients in each country were followed as controls (group B).
RESULTS: At six months, BTN volume significantly decreased in group A (15.1±3.1?mL vs. 4.2±2.7?mL; p<0.0001), whereas it remained unchanged in group B (14.4±3.3?mL vs. 15.2±3.5?mL). The baseline volume was larger in the Italian series (16.4±2.5?mL vs. 13.9±3.3?mL, p=0.009). However, at six months, there was no significant difference between the Korean group and the Italian group (3.7±2.9?mL vs. 5.5±2.2?mL). Both cosmetic and compressive symptoms significantly improved (3.6±0.5 vs. 1.7±0.4 and 3.6±1.9 vs. 0.4±0.7, respectively; p<0.001). No side effects occurred.
CONCLUSIONS: RFA was effective in reducing the volume of BTN. The outcome was similar in centers with different experience in the moving-shot technique.
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MESH
Adult, Aged, Aged, 80 and over, Biopsy, Catheter Ablation/*methods, Electrodes, Female, Humans, Italy, Male, Middle Aged, Patient Safety, Prospective Studies, Seoul, Thyroid Gland/ultrasonography, Thyroid Nodule/*diagnosis/*radiotherapy/ultrasonography, Treatment Outcome, Ultrasonography, Interventional
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