Cho, Nam H; Kim, Kyoung Min; Choi, Sung Hee; Park, Kyong Soo; Jang, Hak Chul; Kim, Sung Soo; Sattar, Naveed; Lim, Soo
Diabetes care
2015Jul ; 38 ( 7 ) :1333-8.
PMID : 25986660
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Cho, Nam H - Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
Kim, Kyoung Min - Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Choi, Sung Hee - Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Park, Kyong Soo - Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jang, Hak Chul - Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Kim, Sung Soo - Center for Genome Science, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon-gun, Republic of Korea.
Sattar, Naveed - Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, Glasgow, U.K.
Lim, Soo - Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Republic of Korea limsoo@snu.ac.kr.
ABSTRACT
OBJECTIVE: No prospective, community-based cohort studies have investigated the association between blood pressure and diabetes in Asian ethnicity. We investigated this issue in a 10-year prospective, community-based study of Koreans. RESEARCH DESIGN AND
METHODS: We studied whether high blood pressure was associated with the development of diabetes in a population-based cohort, where we sampled ??,000 random subjects each from rural and urban areas (age range 40-69 years) during 2001-2010. Among 10,038 subjects, 8,359 without diabetes at baseline were categorized into normal (n = 4,809), prehypertension (n = 2,141), stage 1 hypertension (n = 804), and stage 2 hypertension (n = 605) groups, according to their blood pressure readings of <120/80 mmHg, 120-139/80-89 mmHg, 140-159/90-99 mmHg, and ??60/100 mmHg, respectively. The development of diabetes was defined as a fasting glucose concentration of ??26 mg/dL or a postload glucose concentration of ??00 mg/dL, based on a 75-g oral glucose tolerance test, or the use of antidiabetic medication.
RESULTS: During the 10-year follow-up period, diabetes developed in 1,195 subjects (14.3%). The incidence of diabetes increased from 11.1% in the normal group to 17.0% in the prehypertension group, 17.7% in the stage 1 hypertension group, and 25.8% in the stage 2 hypertension group (P < 0.001). After adjusting for anthropometric factors; family history of diabetes; biochemical parameters including C-reactive protein, A1C, and fasting glucose and postload 2-h glucose levels; and the use of lipid-lowering medications, the hazard risks of diabetes development were 1.23 (95% CI 1.06-1.42), 1.26 (1.04-1.54), and 1.60 (1.30-1.96), respectively, in the prehypertension, stage 1 hypertension, and stage 2 hypertension groups.
CONCLUSIONS: Our findings indicate a grade association of baseline blood pressure with the development of diabetes in Korean individuals. CI - ??2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
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MESH
Adult, Aged, Asian Continental Ancestry Group/genetics/*statistics & numerical data, Blood Pressure/physiology, Diabetes Mellitus/*epidemiology, Female, Glucose Tolerance Test, Humans, Hypertension/complications/*epidemiology, Incidence, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Republic of Korea/epidemiology, Risk Factors
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