Efficacy and Safety of Radiofrequency Ablation for Treatment of Locally Recurrent Thyroid Cancers Smaller than 2 cm.

Kim, Ji-hoon; Yoo, Won Sang; Park, Young Joo; Park, Do Joon; Yun, Tae Jin; Choi, Seung Hong; Sohn, Chul-Ho; Lee, Kyu Eun; Sung, Myung-Whun; Youn, Yeo-Kyu; Kim, Kwang Hyun; Cho, Bo Youn
Radiology
2015Sep ; 276 ( 3 ) :909-18.
저자 상세정보
Kim, Ji-hoon -
Yoo, Won Sang -
Park, Young Joo -
Park, Do Joon -
Yun, Tae Jin -
Choi, Seung Hong -
Sohn, Chul-Ho -
Lee, Kyu Eun -
Sung, Myung-Whun -
Youn, Yeo-Kyu -
Kim, Kwang Hyun -
Cho, Bo Youn -
ABSTRACT
PURPOSE: To evaluate the efficacy and safety of radiofrequency ablation (RFA) for localized small recurrent thyroid cancers less than 2 cm by comparing them with those at repeat surgery. MATERIALS AND

METHODS: This retrospective study was institutional review board-approved, and informed consent was waived. From December 2008 to December 2011, this study evaluated 73 patients (17 men and 56 women; age, 50.3 years 짹 13.6) with recurrent thyroid cancer who had been treated with RFA (n = 27) or repeat surgery (n = 46) who met the following criteria: (a) three or fewer recurrences or lesions with high probability of recurrence at ultrasonography; (b) no tumor other than the target tumors; and (c) at least 1 year of follow-up. RFA was recommended and performed in cases of surgical ineligibility, such as patient refusal and poor medical condition. Recurrence-free survival rates and posttreatment complication rates (eg, hoarseness and hypocalcemia) were compared between RFA and reoperation groups after adjustment with weighted analysis by using inverse probability of treatment weights.

RESULTS: After this adjustment, the 1- and 3-year recurrence-free survival rates were comparable (P = .681) for RFA (96.0% and 92.6%, respectively) and reoperation (92.2% and 92.2%, respectively) groups. The posttreatment hoarseness rate did not differ between the RFA (7.3% [1.8 of 24]) and reoperation (9.0% [3.6 of 39.5]) groups (P = .812), and posttreatment hypocalcemia occurred exclusively in the reoperation group (11.6% [4.6 of 39.5]) but not in the RFA group (0% [0 of 24]) (P = .083). CONCLUSION: RFA may be an effective and safe alternative to repeat surgery in patients with locally recurrent small thyroid cancers.
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MESH
*Catheter Ablation, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/*pathology/*surgery, Retrospective Studies, Thyroid Neoplasms/*pathology/*surgery, Treatment Outcome, Tumor Burden
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
After this adjustment, the 1- and 3-year recurrence-free survival rates were comparable (P = .681) for RFA (96.0% and 92.6%, respectively) and reoperation (92.2% and 92.2%, respectively) groups.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
건강보험코드