Kim, Ju Youn; Kim, Sung-Hwan; Kim, Sung Su; Lee, Ki Hong; Park, Hyung-Wook; Cho, Jeong-Gwan; Uhm, Jae-Sun; Joung, Boyoung; Pak, Hui-Nam; Lee, Moon-Hyoung; Park, Seung-Jung; On, Young Keun; Kim, June Soo; Lim, Hong Euy; Shim, Jaemin; Choi, Jong-Il; Park, Sang Weon; Kim, Young-Hoon; Lee, Woo Seok; Kim, Jun; Nam, Gi-Byoung; Choi, Kee-Joon; Kim, You-Ho; Oh, Yong-Seog; Lee, Man-Young; Rho, Tai-Ho
International journal of cardiology
2015NA ; 187 ( 1 ) :340-4.
PMID : 25839639
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Kim, Ju Youn - Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
Kim, Sung-Hwan - Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
Kim, Sung Su - Heart Research Center, Chonnam National University Hospital, Chonnam National University.
Lee, Ki Hong - Heart Research Center, Chonnam National University Hospital, Chonnam National University.
Park, Hyung-Wook - Heart Research Center, Chonnam National University Hospital, Chonnam National University.
Cho, Jeong-Gwan - Heart Research Center, Chonnam National University Hospital, Chonnam National University.
Uhm, Jae-Sun - Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine.
Joung, Boyoung - Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine.
Pak, Hui-Nam - Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine.
Lee, Moon-Hyoung - Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine.
Park, Seung-Jung - Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine.
On, Young Keun - Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Kim, June Soo - Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Lim, Hong Euy - Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital.
Shim, Jaemin - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital.
Choi, Jong-Il - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital.
Park, Sang Weon - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital.
Kim, Young-Hoon - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital.
Lee, Woo Seok - Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Kim, Jun - Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Nam, Gi-Byoung - Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Choi, Kee-Joon - Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Kim, You-Ho - Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Oh, Yong-Seog - Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. Electronic address oys@catholic.ac.kr.
Lee, Man-Young - Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. Electronic address myleecardio@catholic.ac.kr.
Rho, Tai-Ho - Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
ABSTRACT
BACKGROUND: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. METHODS AND
RESULTS: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3%]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6%) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2% in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7%) had an episode of appropriate ICD therapy afterwards.
CONCLUSIONS: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before. CI - Copyright ??2015 Elsevier Ireland Ltd. All rights reserved.
keyword
Brugada syndrome; Implantable cardioverter-defibrillator; Replacement
MESH
Adult, Brugada Syndrome/*therapy, *Defibrillators, Implantable, Female, Humans, Male, Middle Aged, Retrospective Studies
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