Doo, Miae; Won, Sungho; Kim, Yangha
Nutrition (Burbank, Los Angeles County, Calif.)
2015May ; 31 ( 5 ) :653-8.
PMID : 25837208
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Doo, Miae - Department of Nutritional Science and Food Management, Ewha Womans University, Ewhayeodae-gil, Seoul, Korea.
Won, Sungho - Department of Public Health Science, School of Public Health, Seoul National University, Kwanak-ro, Seoul, Korea.
Kim, Yangha - Department of Nutritional Science and Food Management, Ewha Womans University, Ewhayeodae-gil, Seoul, Korea. Electronic address yhmoon@ewha.ac.kr.
ABSTRACT
OBJECTIVE: The apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOB rs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals.
METHODS: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOB rs1469513 on traits, the interaction of APOB rs1469513 and dietary intake on traits were analyzed.
RESULTS: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P?=?0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOB rs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m(2) versus AG+GG 24.94 kg/m(2), P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele.
CONCLUSIONS: Our findings support a significant association between the APOB rs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs. CI - Copyright ??2015 Elsevier Inc. All rights reserved.
keyword
APOB; Gene-diet interaction; Lipid profile; Obesity; rs1469513
MESH
Adult, Apolipoproteins B/*genetics, Asian Continental Ancestry Group/genetics, Body Mass Index, Body Weight/*genetics, Cholesterol/blood, Dietary Fats/*adverse effects, Female, Genetic Predisposition to Disease, Humans, Lipoproteins, LDL/blood, Male, Middle Aged, Obesity/blood/*diet therapy/*genetics, Polymorphism, Genetic, Risk Factors
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