Lee, AeJin; Jeon, Kyeong Jin; Kim, Min Soo; Kim, Hye-Kyeong; Han, Sung Nim
Nutrition research (New York, N.Y.)
2015Apr ; 35 ( 4 ) :301-8.
PMID : 25753918
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Lee, AeJin -
Jeon, Kyeong Jin -
Kim, Min Soo -
Kim, Hye-Kyeong -
Han, Sung Nim -
ABSTRACT
Obesity has been reported to impair immune functions and lead to low-grade long-term inflammation; however, studies that have investigated the impact of weight loss on these among the young and slightly obese are limited. Thus, we investigated the effect of a 12-week weight management program with behavioral modifications on cell-mediated immune functions and inflammatory responses in young obese participants. Our hypothesis was that weight loss would result in improved immune functions and decreased inflammatory responses. Sixty-four participants (45 obese and 19 normal weight) finished the program. Obese (body mass index ??5) participants took part in 5 group education and 6 individual counseling sessions. Normal-weight (body mass index 18.5-23) participants only attended 6 individual sessions. The goal for the obese was to lose 0.5 kg/wk by reducing their intake by 300 to 500 kcal/d and increasing their physical activity. Program participation resulted in a modest but significant decrease in weight (2.7 ± 0.4 kg, P < .001) and lipopolysaccharide-stimulated interleukin-1β production (from 0.85 ± 0.07 to 0.67 ± 0.07 ng/mL, P < .05) in the obese. In the obese group, increase in phytohemagglutinin-stimulated interleukin-10 production, a TH2 and anti-inflammatory cytokine, approached significance after program participation (from 6181 ± 475 to 6970 ± 632 pg/mL, P = .06). No significant changes in proliferative responses to the optimal concentration of concanavalin A or phytohemagglutinin were observed in the obese after program participation. Collectively, modest weight loss did not change the cell-mediated immune functions significantly but did attenuate the inflammatory response in young and otherwise healthy obese adults. CI - Copyright ??2015 Elsevier Inc. All rights reserved.
keyword
Cell-mediated immune response; Inflammatory response; Obesity; Weight loss
MESH
Adipokines/blood, Adult, Asian Continental Ancestry Group, *Behavior Therapy, Blood Cell Count, Body Mass Index, Body Weight, Cell Proliferation, Cytokines/blood, Diet, Reducing, Energy Intake, Female, *Food Habits, Health Behavior, Humans, Inflammation/therapy, Leukocytes, Mononuclear/metabolism, Lymphocytes/cytology/metabolism, Male, Middle Aged, Motor Activity, Obesity/*therapy, Republic of Korea, *Weight Loss, *Weight Reduction Programs, Young Adult
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