KCTBASE

Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study.

Song, Yun-Mi; Sung, Joohon; Lee, Kayoung

Clinical and experimental nephrology
2015Oct ; 19 ( 5 ) :887-94.

PMID : 25634252

저자 상세정보

Song, Yun-Mi -
Sung, Joohon -
Lee, Kayoung -

ABSTRACT

BACKGROUND: To examine cross-sectional and longitudinal relationships, including genetic and environmental correlations, of metabolic syndrome (MetS) and obesity with kidney function.

METHODS: Subjects were 3,437 Korean adults of the Healthy Twin Study for cross-sectional relationships and 1,881 participants for longitudinal relationships (follow-up interval 3.7 짹 1.4 years). Obesity (body mass index ??25 vs. <25 kg/m(2)), MetS, and chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m(2) using the modification of diet in renal disease study equation)] were categorized at baseline and follow-up.

RESULTS: The prevalence and incidence of chronic kidney disease were 2.5 and 3.3 %, respectively. Compared to individuals without obesity and MetS, prevalent CKD was associated with MetS regardless of weight status [adjusted odds ratio (AOR) 4.19 for those with MetS but without obesity; AOR 4.63 for those with MetS and obesity]. Incident CKD was associated with obesity regardless of baseline metabolic status (AOR 2.03 for those with obesity but without MetS; AOR 2.85 for those with obesity and MetS). MetS at follow-up was associated with incident CKD regardless of baseline MetS (AOR 2.42-2.52). Sex-adjusted bivariate analyses show inverse environmental correlations of the number of MetS components and BMI at baseline, with eGFR at baseline and follow-up (? E, -0.26 to -0.42, P < 0.001).

CONCLUSIONS: MetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS. Incident CKD is also associated with MetS at follow-up regardless of baseline MetS. These associations appear to be explained by shared environmental factors.

keyword

Chronic kidney disease (CKD); Metabolic syndrome; Obesity

링크

PubMed

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

MetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

10.1007/s10157-015-1083-5

KCD코드

ICD 03

건강보험코드