Ethanol ablation of predominantly cystic thyroid nodules: evaluation of recurrence rate and factors related to recurrence.

Suh, C H; Baek, J H; Ha, E J; Choi, Y J; Lee, J H; Kim, J K; Chung, K-W; Kim, T Y; Kim, W B; Shong, Y K
Clinical radiology
2015Jan ; 70 ( 1 ) :42-7.
저자 상세정보
Suh, C H -
Baek, J H -
Ha, E J -
Choi, Y J -
Lee, J H -
Kim, J K -
Chung, K-W -
Kim, T Y -
Kim, W B -
Shong, Y K -
AIM: To evaluate recurrence rate and associated risk factors for recurrence after ethanol ablation (EA) in patients with predominantly cystic thyroid nodules. MATERIALS AND

METHODS: This observational study was approved by the Ethics Committee of the Institutional Review Board and informed consent for procedures was obtained. From April 2009 to April 2013, 107 consecutive patients with predominantly cystic nodules were treated using EA. Recurrence was defined as nodules showing a residual solid portion with internal vascularity, cosmetic problems remaining, or persistent symptoms, and patients who requested additional therapy to resolve their symptomatic or cosmetic problems. Delayed recurrence was defined as treated nodules that showed no recurrent features at 1 month, but showed newly developed recurrent features during the longer follow-up period. Multivariate analysis was used for variables to demonstrate the independent factors related to volume reduction.

RESULTS: One month after EA, 18.7% of patients (20/107) showed recurrence. Among 87 patients with non-recurrence, 24.1% (21/87) showed delayed recurrence. The total recurrence rate was 38.3% (41/107). Patients with recurrence (n?=?41) were treated using radiofrequency ablation (n?=?28), second EA (n?=?4), and refused further treatment (n?=?9). These patients responded well to repeat EA and radiofrequency ablation. Multivariate analysis demonstrated that the initial nodule volume (>20?ml; p?1; p?
CONCLUSIONS: The results revealed that although EA seemed to be effective during the initial period, delayed recurrence should be considered during longer-term follow-up. The independent predictors of recurrence were initial volume (>20?ml) and vascularity. CI - Copyright ??2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Adolescent, Adult, Aged, Aged, 80 and over, Catheter Ablation/methods, Child, Cysts/*therapy/ultrasonography, Ethanol/therapeutic use, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/*epidemiology, Risk Factors, Thyroid Nodule/*therapy/ultrasonography, Treatment Outcome, Ultrasonography, Interventional/methods, Young Adult

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
The total recurrence rate was 38.3% (41/107). Patients with recurrence (n = 41) were treated using radiofrequency ablation (n = 28), second EA (n = 4), and refused further treatment (n = 9).
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03