Ethanol ablation of predominantly cystic thyroid nodules: evaluation of recurrence rate and factors related to recurrence.

Suh, C H; Baek, J H; Ha, E J; Choi, Y J; Lee, J H; Kim, J K; Chung, K-W; Kim, T Y; Kim, W B; Shong, Y K
Clinical radiology
2015Jan ; 70 ( 1 ) :42-7.
저자 상세정보
Suh, C H -
Baek, J H -
Ha, E J -
Choi, Y J -
Lee, J H -
Kim, J K -
Chung, K-W -
Kim, T Y -
Kim, W B -
Shong, Y K -
ABSTRACT
AIM: To evaluate recurrence rate and associated risk factors for recurrence after ethanol ablation (EA) in patients with predominantly cystic thyroid nodules. MATERIALS AND

METHODS: This observational study was approved by the Ethics Committee of the Institutional Review Board and informed consent for procedures was obtained. From April 2009 to April 2013, 107 consecutive patients with predominantly cystic nodules were treated using EA. Recurrence was defined as nodules showing a residual solid portion with internal vascularity, cosmetic problems remaining, or persistent symptoms, and patients who requested additional therapy to resolve their symptomatic or cosmetic problems. Delayed recurrence was defined as treated nodules that showed no recurrent features at 1 month, but showed newly developed recurrent features during the longer follow-up period. Multivariate analysis was used for variables to demonstrate the independent factors related to volume reduction.

RESULTS: One month after EA, 18.7% of patients (20/107) showed recurrence. Among 87 patients with non-recurrence, 24.1% (21/87) showed delayed recurrence. The total recurrence rate was 38.3% (41/107). Patients with recurrence (n?=?41) were treated using radiofrequency ablation (n?=?28), second EA (n?=?4), and refused further treatment (n?=?9). These patients responded well to repeat EA and radiofrequency ablation. Multivariate analysis demonstrated that the initial nodule volume (>20?ml; p?1; p?
CONCLUSIONS: The results revealed that although EA seemed to be effective during the initial period, delayed recurrence should be considered during longer-term follow-up. The independent predictors of recurrence were initial volume (>20?ml) and vascularity. CI - Copyright ??2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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MESH
Adolescent, Adult, Aged, Aged, 80 and over, Catheter Ablation/methods, Child, Cysts/*therapy/ultrasonography, Ethanol/therapeutic use, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/*epidemiology, Risk Factors, Thyroid Nodule/*therapy/ultrasonography, Treatment Outcome, Ultrasonography, Interventional/methods, Young Adult
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The total recurrence rate was 38.3% (41/107). Patients with recurrence (n = 41) were treated using radiofrequency ablation (n = 28), second EA (n = 4), and refused further treatment (n = 9).
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
https://pubmed.ncbi.nlm.nih.gov/25443776/
KCD코드
ICD 03
건강보험코드