Lee, Jee-Yon; Chu, Sang-Hui; Jeon, Justin Y; Lee, Mi-Kyung; Park, Ji-Hye; Lee, Duk-Chul; Lee, Ji-Won; Kim, Nam-Kyu
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
2014Dec ; 46 ( 12 ) :1126-32.
PMID : 25442120
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Lee, Jee-Yon - Department of Family Medicine, Yonsei University, College of Medicine, Republic of Korea.
Chu, Sang-Hui - Department of Clinical Nursing Science, Yonsei University, College of Nursing, Nursing Policy Research Institute, Biobehavioural Research Center, Republic of Korea.
Jeon, Justin Y - Department of Sport and Leisure Studies, Sports Medicine Laboratory, Yonsei University, Republic of Korea.
Lee, Mi-Kyung - Department of Sport and Leisure Studies, Sports Medicine Laboratory, Yonsei University, Republic of Korea.
Park, Ji-Hye - Department of Sport and Leisure Studies, Sports Medicine Laboratory, Yonsei University, Republic of Korea.
Lee, Duk-Chul - Department of Family Medicine, Yonsei University, College of Medicine, Republic of Korea.
Lee, Ji-Won - Department of Family Medicine, Yonsei University, College of Medicine, Republic of Korea. Electronic address indi5645@yuhs.ac.
Kim, Nam-Kyu - Department of General Surgery, Yonsei University College of Medicine, Republic of Korea. Electronic address namkyuk@yuhs.ac.
ABSTRACT
BACKGROUND: Probiotics may help resolve bowel symptoms and improve quality of life. We investigated the effects of 12 weeks of probiotics administration in colorectal cancer patients.
METHODS: We conducted a double-blind, randomized, placebo-controlled trial. The participants took probiotics (Lacidofil) or placebo twice a day for 12 weeks. The cancer-related quality of life (FACT), patient's health-9 (PHQ-9), and bowel symptom questionnaires were completed by each participant.
RESULTS: We obtained data for 32 participants in the placebo group and 28 participants in the probiotics group. The mean ages of total participants were 56.18 ± .86 years and 58.3% were male. Administration of probiotics significantly decreased the proportion of patients suffering from irritable bowel symptoms (0 week vs. 12 week; 67.9% vs. 45.7%, p=0.03), improved colorectal cancer-related FACT (baseline vs. 12 weeks: 19.79 ± 4.66 vs. 21.18 ± 3.67, p=0.04) and fatigue-related FACT (baseline vs. 12 weeks: 43.00 (36.50-45.50) vs. 44.50 (38.50-49.00), p=0.02) and PHQ-9 scores (0 weeks vs. 12 weeks; 3.00 (0-8.00) vs. 1.00 (0-3.00), p=0.01). We found significant differences in changes of the proportion of patients with bowel symptoms (p<0.05), functional well-being scores (p=0.04) and cancer-related FACT scores (p=0.04) between the two groups. CONCLUSION: Probiotics improved bowel symptoms and quality of life in colorectal cancer survivors. CI - Copyright ??2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
keyword
Bowel symptoms; Cancer survivors; Colorectal cancer; Probiotics
MESH
Adult, Aged, Aged, 80 and over, Colorectal Neoplasms/*complications, Double-Blind Method, Female, Humans, Irritable Bowel Syndrome/etiology/*therapy, Male, Middle Aged, Probiotics/*therapeutic use, *Quality of Life, *Survivors, Treatment Outcome
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