Park, Se Woo; Lee, Hang Lak; Ju, Yong Won; Jun, Dae Won; Lee, Oh Young; Han, Dong Soo; Yoon, Byung Chul; Choi, Ho Soon; Hahm, Joon Soo
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2015Feb ; 19 ( 2 ) :242-50.
PMID : 25338660
ÀúÀÚ »ó¼¼Á¤º¸
Park, Se Woo -
Lee, Hang Lak -
Ju, Yong Won -
Jun, Dae Won -
Lee, Oh Young -
Han, Dong Soo -
Yoon, Byung Chul -
Choi, Ho Soon -
Hahm, Joon Soo -
ABSTRACT
BACKGROUND: The relationship between fat distribution and lymph node metastasis has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node metastasis in gastric cancer. MATERIALS AND
METHODS: Metastatic lymph node ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected lymph nodes. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) >0.29.
RESULTS: With lymph node metastasis as a dependent variable, the following factors were significant in multivariate analysis among 495 patients: pathologic T stage (P?
CONCLUSIONS: Visceral obesity defined by higher visceral to total fat area ratio was significantly associated with decreased MLR.
Obesity Visceral fat area Lymph node Metastasis Gastric cancer
MESH
Adenocarcinoma/complications/*secondary/surgery, Aged, Blood Vessels/pathology, Female, Humans, *Lymph Node Excision, Lymph Nodes/*pathology, Lymphatic Metastasis, Lymphatic Vessels/pathology, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Obesity, Abdominal/*complications, Prognosis, Proportional Hazards Models, Retrospective Studies, Stomach Neoplasms/complications/*pathology/surgery, Subcutaneous Fat
¸µÅ©