Radiofrequency ablation for autonomously functioning thyroid nodules: a multicenter study.

Sung, Jin Yong; Baek, Jung Hwan; Jung, So Lyung; Kim, Ji-hoon; Kim, Kyu Sun; Lee, Ducky; Kim, Won Bae; Na, Dong Gyu
Thyroid : official journal of the American Thyroid Association
2015Jan ; 25 ( 1 ) :112-7.
저자 상세정보
Sung, Jin Yong -
Baek, Jung Hwan -
Jung, So Lyung -
Kim, Ji-hoon -
Kim, Kyu Sun -
Lee, Ducky -
Kim, Won Bae -
Na, Dong Gyu -
ABSTRACT
BACKGROUND: The purpose of this study is to validate the generalizability of the efficacy and safety of radiofrequency (RF) ablation for treating autonomously functioning thyroid nodules (AFTN) in a large population multicenter study.

METHODS: This study included 44 patients from 5 institutions who refused or were not suitable for surgery or radioiodine therapy. Twenty-three patients were affected by a toxic nodule and 21 by a pretoxic nodule. RF ablation was performed using an 18-gauge, internally cooled electrode. Nodule volume, thyroid function, scintigraphy, symptom/cosmetic scores, and complications were evaluated before treatment and during each follow-up.

RESULTS: The mean follow-up period was 19.9짹12.6 months. The mean nodule volume was initially 18.5짹30.1?mL and significantly decreased after treatment at 1 month (11.8짹26.9?mL, p<0.001) and the last month (4.5짹9.8?mL, p<0.001). Significant improvement of triiodothyronine, free thyroxine, and thyrotropin was observed at the last follow-up. Regarding scintigraphy, 35 hot nodules became cold or were normal when scanned and 9 decreased uptake, although they remained hot nodules. The mean symptom and cosmetic scores were significantly reduced at the last follow-up. No major complications were encountered.

CONCLUSIONS: This multicenter study validated the efficacy and safety of RF ablation for treating AFTN; RF ablation can be considered an alternative to surgery or radioiodine therapy.
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MESH
Adolescent, Adult, Aged, Catheter Ablation/adverse effects/*methods, Female, Humans, Male, Middle Aged, Thyroid Nodule/blood/*therapy, Thyrotropin/blood, Thyroxine/blood, Treatment Outcome, Triiodothyronine/blood, Young Adult
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The mean nodule volume was initially 18.5+/-30.1 mL and significantly decreased after treatment at 1 month (11.8+/-26.9 mL, p<0.001) and the last month (4.5+/-9.8 mL, p<0.001).
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1089/thy.2014.0100.
KCD코드
ICD 03
건강보험코드