Bae, Hyoung Won; Lee, Naeun; Lee, Hye Sun; Hong, Samin; Seong, Gong Je; Kim, Chan Yun
PloS one
2014NA ; 9 ( 9 ) :e108226.
PMID : 25254373
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Bae, Hyoung Won -
Lee, Naeun -
Lee, Hye Sun -
Hong, Samin -
Seong, Gong Je -
Kim, Chan Yun -
ABSTRACT
BACKGROUND/AIMS: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.
METHODS: A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.
RESULTS: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for high-tension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.
CONCLUSIONS: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.
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MESH
Asian Continental Ancestry Group, European Continental Ancestry Group, Glaucoma, Open-Angle/*epidemiology/*etiology, Humans, Hypertension/*complications, Odds Ratio, Population Surveillance, Publication Bias, Risk Factors
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