Hwang, Minki; Lee, Hancheol; Lee, Young-Seon; Chung, Soonwon; Choi, Sung Hwan; Shim, Eun Bo; Pak, Hui-Nam
Progress in biophysics and molecular biology
2014Sep ; 116 ( 1 ) :33-9.
PMID : 25236363
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Hwang, Minki - Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea.
Lee, Hancheol - Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea.
Lee, Young-Seon - Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea.
Chung, Soonwon - Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea.
Choi, Sung Hwan - CU Medical Systems Incorporation, Wonju, Gangwon-Do, Republic of Korea.
Shim, Eun Bo - Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea. Electronic address ebshim@kangwon.ac.kr.
Pak, Hui-Nam - Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea. Electronic address hnpak@yuhs.ac.
ABSTRACT
INTRODUCTION: Although ventricular tachycardia/fibrillation (VT/VF) develops suddenly with catastrophic results, its prediction is limited. We tested the fibrillation number (FibN) for potential predictor of VT/VF using clinical data of implantable cardioverter-defibrillator (ICD) patients after validating the number by computational modeling.
METHODS: For clinical application of FibN, we used electrocardiography and echocardiography data: QRS width, QTc, and left ventricular (LV) end-systolic dimension (FibNVT/VF1) or LV end-diastolic dimension (FibNVT/VF2). We compared the maintenance duration of VT/VF for various FibN values using computational modeling, and tested FibNVT/VF in 142 patients with ICD for secondary prevention and 426 patients in age-sex matched control group (81.9% male, 56.1?±?12.3 years old).
RESULTS: 1. Computational results showed a positive correlation between VT/VF maintenance duration and FibN (R?=?0.82, p?
keyword
Arrhythmogenecity; Computational modeling; Implantable cardioverter defibrillator; Ventricular fibrillation; Ventricular tachycardia
MESH
Computer Simulation, *Defibrillators, Implantable, Diagnosis, Computer-Assisted/methods, Female, Heart Conduction System/*physiopathology, Heart Ventricles/*physiopathology, Humans, Male, Middle Aged, *Models, Cardiovascular, Patient-Specific Modeling, Reproducibility of Results, Sensitivity and Specificity, Therapy, Computer-Assisted/methods, Ventricular Fibrillation/diagnosis/*physiopathology/*prevention & control
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