Lee, Chang-Hyung; Lee, Sooji; Kang, Hyojeong; Jung, Da-Eun; Song, Yun-Mi; Lee, Kayoung; Lee, Kyungtai; Hwang, Jihye; Sung, Joohon
Twin research and human genetics : the official journal of the International Society for Twin Studies
2014Apr ; 17 ( 2 ) :121-6.
PMID : 24618045
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Lee, Chang-Hyung - Rehabilitation Medicine, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Mulgeum, Yangsan, Gyeongnam, South Korea.
Lee, Sooji - Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Kang, Hyojeong - Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jung, Da-Eun - Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Song, Yun-Mi - Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Lee, Kayoung - Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Lee, Kyungtai - KT Lee Orthopedic Hospital, Seoul, Korea.
Hwang, Jihye - Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Sung, Joohon - Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
ABSTRACT
Hallux valgus (HV) is a common foot deformity of multifactorial etiology, but knowledge about the relative importance of genetics and environments on HV has been limited. In order to estimate genetic influences on HV, 1,265 adults, including 175 monozygotic twin (MZ) pairs, 31 dizygotic twin (DZ) pairs, and 853 first-degree singleton family members of the twins were included from the Healthy Twin study, a population-based twin-family cohort in Korea. All participants underwent foot examination and weight-bearing radiographic assessment (anterior-posterior and lateral) in addition to a general health survey. Of the subjects, 208 (16.4%) were classified as HV (as HV angle >20°). The genetic influence on HV was estimated to be substantial; the heritability of HV was 0.51 (95% CI 0.42-0.59) and the heritability of HV angle was 0.47 (0.38-0.56), while contributions from shared environmental effects were negligible. These findings suggest that genetic factors play an important role in determining HV deformity.
foot disease, hallux valgus deformity of foot genetic epidemiology twin research Koreans Asiatic races
MESH
Adult, Asian Continental Ancestry Group/*genetics, Female, Hallux Valgus/*epidemiology/*genetics/radiography, Humans, Male, Republic of Korea, Twins, Dizygotic/*genetics, Twins, Monozygotic/*genetics
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