Portal hypertensive enteropathy diagnosed by capsule endoscopy in cirrhotic patients: a nationwide multicenter study.

Jeon, Seong Ran; Kim, Jin-Oh; Kim, Ji-Beom; Ye, Byong Duk; Chang, Dong Kyung; Shim, Ki-Nam; Cheung, Dae Young; Kim, Jin Soo; Choi, Myung Gyu; Song, Hyun Joo; Lim, Yun Jeong; Park, Soo Jung; Kim, Ji Hyun; Moon, Jeong Seop; Jeen, Yoon Tae
Digestive diseases and sciences
2014May ; 59 ( 5 ) :1036-41.
저자 상세정보
Jeon, Seong Ran -
Kim, Jin-Oh -
Kim, Ji-Beom -
Ye, Byong Duk -
Chang, Dong Kyung -
Shim, Ki-Nam -
Cheung, Dae Young -
Kim, Jin Soo -
Choi, Myung Gyu -
Song, Hyun Joo -
Lim, Yun Jeong -
Park, Soo Jung -
Kim, Ji Hyun -
Moon, Jeong Seop -
Jeen, Yoon Tae -
ABSTRACT
BACKGROUND AND AIM: Due to the limited data on portal hypertensive enteropathy (PHE), the prevalence of and clinical factors related to PHE remain unclear. This study determined the prevalence of PHE using capsule endoscopy (CE) and PHE-related clinical factors.

METHODS: This was a retrospective multicenter study using the Capsule Endoscopy Nationwide Database Registry. From 2,879 cases that underwent CE, 45 cirrhosis patients with portal hypertension (PH) were enrolled and divided into PHE (n = 18) and non-PHE (n = 27) groups. From computed tomography (CT) images, six secondary changes due to PH were scored to give a total CT score of 0-6. The main outcome variable was the prevalence of PHE and PHE-related clinical factors.

RESULTS: The prevalence of PHE was 40 %. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 % (vs. 7.4 %, p = 0.001) and varices in 38.9 % (vs. 0 %, p = 0.001). Active bleeding was observed in 16.6 and 3.7 %, respectively, but this difference was not significant. In the univariate analysis, Child-Turcotte-Pugh class C (p = 0.002) and a high CT score (?? vs. <3, p = 0.004) were significantly associated with PHE. However, only a high CT score was significant in the multivariate analysis (odds ratio 11.19; 95 % confidence interval, 1.59-infinity; p = 0.040).

CONCLUSIONS: The prevalence of PHE was 40 %, and it might be more prevalent in cirrhosis patients with PH who have a high CT score. CE is a useful diagnostic tool for evaluating PHE in cirrhosis patients with PH.
Capsule endoscopy Enteropathy Portal hypertension Liver cirrhosis
MESH
Adult, Aged, *Capsule Endoscopy, Female, Humans, Hypertension, Portal/*complications, Intestinal Diseases/*classification/*diagnosis, Liver Cirrhosis/*complications, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Factors, Treatment Outcome
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The prevalence of PHE was 40 %. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 % (vs. 7.4 %, p = 0.001) and varices in 38.9 % (vs. 0 %, p = 0.001) using endoscopy.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
1007/s10620-014-3036-3
KCD코드
ICD 03
건강보험코드