Lee, Young Ho; Song, Gwan Gyu
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2014May ; 35 ( 5 ) :643-51.
PMID : 24477323
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Lee, Young Ho -
Song, Gwan Gyu -
ABSTRACT
The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met or the peroxisome proliferator-activated receptor-gamma (PPARγ) Pro12Ala polymorphisms are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between the COMT Val158Met and the PPARγ Pro12Ala polymorphisms and AD in subjects. Meta-analysis showed no association between AD and the COMT G allele in any of the study subjects [odds ratio (OR) = 0.972, 95 % confidence intervals (95 % CI) = 0.893-1.059, p = 0.515]. Stratification by ethnicity indicated an association between the COMT GG+GA genotype and AD in an Asian group (OR = 0.702, 95 % CI = 0.517-0.953, p = 0.023), but not in Europeans (OR = 1.058, 95 % CI = 0.868-1.289, p = 0.579). Homozygote contrast analysis showed the same pattern for the COMT GG+GA genotype. Meta-analysis showed no association between AD and the PPARγ polymorphism (OR for the C allele = 0.963, 95 % CI = 0.818-1.134, p = 0.649). This meta-analysis identified an association between AD and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPARγ Pro12Ala polymorphism.
Alzheimer¡¯s disease; COMT; PPAR¥ã; Polymorphism; Meta-analysis
MESH
Alzheimer Disease/*genetics, Asian Continental Ancestry Group/genetics, Catechol O-Methyltransferase/*genetics, European Continental Ancestry Group/genetics, *Genetic Predisposition to Disease, Humans, PPAR gamma/*genetics, *Polymorphism, Single Nucleotide
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