Prognosis of adenosquamous carcinoma compared with adenocarcinoma in uterine cervical cancer: a systematic review and meta-analysis of observational studies.

Lee, Jung-Yun; Lee, Chulmin; Hahn, Seokyung; Kim, Min A; Kim, Hee Seung; Chung, Hyun Hoon; Kim, Jae-Weon; Park, Noh Hyun; Song, Yong-Sang
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
2014Feb ; 24 ( 2 ) :289-94.
저자 상세정보
Lee, Jung-Yun -
Lee, Chulmin -
Hahn, Seokyung -
Kim, Min A -
Kim, Hee Seung -
Chung, Hyun Hoon -
Kim, Jae-Weon -
Park, Noh Hyun -
Song, Yong-Sang -
ABSTRACT
OBJECTIVE: The aim of this study was to compare the survival outcomes of adenosquamous carcinoma (ASC) and adenocarcinoma (AC) of the cervix.

METHODS: We searched PubMed and Embase for observational studies that compared the outcomes of 2 histologic subtypes. Hazards ratios (HRs) with 95% confidence intervals (CIs) were calculated with a fixed effects model.

RESULTS: A total of 17 studies were included in the analyses. Patients with ASC were associated significantly with poorer overall survival (death HR, 1.27; 95% CI, 1.12-1.43; I(2) = 0%) and recurrence-free survival (recurrence HR, 1.43; 95% CI, 1.05-1.95; I(2) = 19.4%) than those with AC. For clinical stages I and II in particular, ASC predicted significantly poorer outcomes compared with AC (death HR, 1.41; 95% CI, 1.17-1.70; I(2) = 0%).

CONCLUSIONS: This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.
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MESH
Adenocarcinoma/diagnosis/*mortality, Carcinoma, Adenosquamous/diagnosis/*mortality, Female, Humans, Observational Studies as Topic, Prognosis, Uterine Cervical Neoplasms/diagnosis/*mortality
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1097/IGC.0000000000000063.
KCD코드
ICD 03
건강보험코드