Kim, Moon Jin; Kim, Seok-Hyun; Kang, Jung Hun; Kim, Hoon Gu; Cho, Yu Ji; Jeong, Yi Yeong; Kim, Ho-Cheol; Lee, Jong Duk; Hwang, Young Sil; Kim, Min-Gyo; Choi, Ja-Yoon; Lee, Gyeong-Won
Chemotherapy
2013NA ; 59 ( 3 ) :159-66.
PMID : 24107481
ÀúÀÚ »ó¼¼Á¤º¸
Kim, Moon Jin -
Kim, Seok-Hyun -
Kang, Jung Hun -
Kim, Hoon Gu -
Cho, Yu Ji -
Jeong, Yi Yeong -
Kim, Ho-Cheol -
Lee, Jong Duk -
Hwang, Young Sil -
Kim, Min-Gyo -
Choi, Ja-Yoon -
Lee, Gyeong-Won -
ABSTRACT
PURPOSE: We investigated the efficacy and toxicity of a biweekly schedule of docetaxel and cisplatin in high-risk patients with unresectable (stages IIIB-IV) non-small cell lung cancer (NSCLC).
METHODS: In this study, 48 high-risk patients with previously untreated locally advanced or metastatic NSCLC were treated with combination chemotherapy consisting of docetaxel 40 mg/m(2) and cisplatin 40 mg/m(2); both drugs were given biweekly, on days 1 and 15, every 4 weeks in an outpatient setting.
RESULTS: Complete response, partial response, and stable disease were observed in 1 (2.1%), 30 [62.5%, 95% confidence interval (CI) 47.9-77.1], and 4 (8.3%) patients. The median overall survival was 15.1 months (95% CI 11.7-18.5) and the median time to progression was 7.5 months (95% CI 6.4-8.6). The major toxicity was grade 3 anemia in 7 (14.6%) patients. Grade 3/4 neutropenia was observed in 5 (10.4%) patients. Among the nonhematologic toxicities, grade 3 infection and grade 3 diarrhea were observed in 5 (10.4%) and 4 (8.3%) patients, respectively. No treatment-related mortality was found.
CONCLUSIONS: As a front-line chemotherapy for high-risk patients with unresectable NSCLC in an outpatient setting, the biweekly schedule of docetaxel and cisplatin showed feasible efficacy with acceptable hematologic toxicities, comparable to the results of previous studies of triweekly or weekly schedules. Additional large randomized studies are needed to optimize the schedule and dosage of combination therapy with docetaxel and cisplatin in high-risk patients with unresectable NSCLC.
na
MESH
Aged, Antineoplastic Agents/adverse effects/*therapeutic use, Carcinoma, Non-Small-Cell Lung/*drug therapy/mortality/pathology, Cisplatin/adverse effects/*therapeutic use, Diarrhea/etiology, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Kaplan-Meier Estimate, Lung Neoplasms/*drug therapy/mortality/pathology, Male, Middle Aged, Neoplasm Staging, Neutropenia/etiology, Positron-Emission Tomography, Taxoids/adverse effects/*therapeutic use, Tomography, X-Ray Computed, Treatment Outcome
¸µÅ©