The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention.

Heo, Jae-Hyeok; Hyon-Lee; Lee, Kyoung-Min
American journal of Alzheimer's disease and other dementias
2013Mar ; 28 ( 2 ) :120-5.
PMID : 23307795
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Heo, Jae-Hyeok -
Hyon-Lee -
Lee, Kyoung-Min -
ABSTRACT
Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer's disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases β-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesis and progression of AD. However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.
Alzheimer’s disease, vitamin C, oxidative stress
MESH
Alzheimer Disease/drug therapy/metabolism/*prevention & control, Antioxidants/physiology/*therapeutic use, Ascorbic Acid/physiology/*therapeutic use, Humans, Oxidative Stress/*physiology
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The efficacy of vitamin C on n the blood–brain barrier dysfunction has been suggested as a new possible therapeutic mechanism in AD.
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DOI
10.1177/1533317512473193
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ICD 03
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