Radiofrequency ablation of benign thyroid nodules does not affect thyroid function in patients with previous lobectomy.

Ha, Eun Ju; Baek, Jung Hwan; Lee, Jeong Hyun; Sung, Jin Yong; Lee, Ducky; Kim, Jae Kyun; Shong, Young Kee
Thyroid : official journal of the American Thyroid Association
2013Mar ; 23 ( 3 ) :289-93.
저자 상세정보
Ha, Eun Ju -
Baek, Jung Hwan -
Lee, Jeong Hyun -
Sung, Jin Yong -
Lee, Ducky -
Kim, Jae Kyun -
Shong, Young Kee -
ABSTRACT
BACKGROUND: Surgical management of symptomatic benign thyroid nodules in patients with previous lobectomy poses a dilemma for physicians. Radiofrequency (RF) ablation may provide a treatment option that avoids surgery and preserves thyroid function. We evaluated whether RF ablation of benign thyroid nodules affects thyroid function in patients with previous lobectomy.

METHODS: A total of 11 patients with 14 thyroid nodules were enrolled using the following criteria: (i) having a predominantly solid nodule; (ii) reporting pressure symptoms or cosmetic problems; (iii) cytological confirmation of benignancy; (iv) no malignant features detected using ultrasound; (v) serum thyroid hormone and thyrotropin (TSH) levels within normal limits; and (vi) refusal of or ineligibility for surgery. Thyroid function, nodule volumes, and clinical concerns were evaluated before RF ablation and during follow-up after RF ablation.

RESULTS: The mean follow-up duration after RF ablation was 43.7짹30.7 months (range=7-92 months). The mean nodule volume was 9.7 mL (0.9-57.6 mL) before the procedure, and was significantly decreased at the last follow-up (p<0.001) with a mean volume reduction rate of 87.2%. The mean symptom score (p=0.003) and cosmetic score (p=0.003) were both significantly decreased at the last follow-up. Levels of TSH, free thyroxine, and triiodothyronine were not significantly different prior to treatment and at the last follow-up (p>0.05), and remained normal in all patients.

CONCLUSIONS: In patients with previous lobectomy, RF ablation should be considered as a first-line treatment for symptomatic benign thyroid nodules to preserve thyroid function.
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MESH
Adult, Catheter Ablation/*methods, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Thyroid Gland/physiology/radiation effects/*surgery, Thyroid Hormones/blood, Thyroid Nodule/*radiotherapy/*surgery, Thyroidectomy/methods, Thyrotropin/blood, Treatment Outcome
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
In patients with previous lobectomy, RFA should be considered as a first-line treatment for symptomatic benign thyroid nodules to preserve thyroid function.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1089/thy.2012.0171.
KCD코드
ICD 03
건강보험코드