Chang, Hyun; Kim, Se Hyun; Cho, Byoung Chul; Yoon, Sang Hyun; Kim, Hye Ryun; Lee, Chang Geol; Kim, Joo Hang
Anticancer research
2012Aug ; 32 ( 8 ) :3515-21.
PMID : 22843939
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Chang, Hyun -
Kim, Se Hyun -
Cho, Byoung Chul -
Yoon, Sang Hyun -
Kim, Hye Ryun -
Lee, Chang Geol -
Kim, Joo Hang -
ABSTRACT
BACKGROUND/AIM: We evaluated the anti-tumor activity and safety of cisplatin with irinotecan (IP) induction chemotherapy followed by chemoradiotherapy with etoposide/cisplatin (EP). PATIENTS AND
METHODS: Induction chemotherapy consisted of irinotecan i.v. and cisplatin i.v. and was administered on day 1 and day 8 of each cycle. Patients underwent two cycles of chemotherapy with a 3-week interval. In the absence of progressive disease, 66 Gy radiation was administered concurrently with etoposide on days 1 to 5 and 29 to 33, as well as with cisplatin on day 1, 8, 29, and 36.
RESULTS: Twenty patients were enrolled between July 2007 and December 2009. This study was closed prematurely due to lack of efficacy in induction chemotherapy. The overall response rate was 45% [95% confidence interval (CI), 25 to 65%], which did not meet the upper limit for first stage rejection of the treatment. The rates of 3-year progression-free survival and overall survival were 17.1% (95% CI, 0 to 36.8%) and 25% (95% CI, 0.2 to 49.8%), respectively. The primary toxicities included neutropenia, diarrhea and fatigue. CONCLUSION: This study failed to demonstrate a benefit for induction chemotherapy which was characterized by suboptimal antitumor activity and was poorly tolerated, with excess treatment-related toxicity.
Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use; Camptothecin/administration & dosage/analogs & derivatives; Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology/radiotherapy; Cisplatin/administration & dosage; Combined Modality Therapy; Disease Progression; Female; Humans; Lung Neoplasms/*drug therapy/pathology/radiotherapy; Male; Middle Aged; Neoplasm Staging
MESH
Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use, Camptothecin/administration & dosage/analogs & derivatives, Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology/radiotherapy, Cisplatin/administration & dosage, Combined Modality Therapy, Disease Progression, Female, Humans, Lung Neoplasms/*drug therapy/pathology/radiotherapy, Male, Middle Aged, Neoplasm Staging
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