Clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer.

Lee, Yoo-Young; Choi, Chel Hun; Sung, Chang Ohk; Do, In-Gu; Hub, Seung Jae; Kim, Ha-Jeong; Kim, Tae-Joong; Lee, Jeong-Won; Bae, Duk-Soo; Kim, Byoung-Gie
Gynecologic oncology
2012Oct ; 127 ( 1 ) :107-13.
저자 상세정보
Lee, Yoo-Young -
Choi, Chel Hun -
Sung, Chang Ohk -
Do, In-Gu -
Hub, Seung Jae -
Kim, Ha-Jeong -
Kim, Tae-Joong -
Lee, Jeong-Won -
Bae, Duk-Soo -
Kim, Byoung-Gie -
ABSTRACT
OBJECTIVE: Immune competence is an important prognostic factor in cancer patients. Surgical management of cancer can cause a variety of immunological disturbances, the clinical consequences of which are still unclear. MATERIALS AND

METHODS: Patients with clinically staged cervical carcinoma (IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea from 1994 to 2007 were retrospectively enrolled. We compared peri-operative peripheral lymphocyte counts, tumor-infiltrating lymphocyte scores, and survival in patients with early cervical cancer treated by abdominal type III radical hysterectomy.

RESULTS: The sample included 756 patients. The median follow-up was 58 months with a range of 3-181 months. There was a positive correlation between pre-operative peripheral lymphocyte counts and tumor infiltrating lymphocyte score. Pre-operative peripheral lymphocyte counts decreased significantly after surgery. In multivariate analyses for recurrence, higher pre-operative peripheral lymphocyte counts and recovery of lymphocyte counts (more than 100/muL from the pre-operative level) on post-operative day 3 were independent positive prognostic factors and LN metastasis was negatively associated with post-operative recovery of peripheral lymphocyte counts. CONCLUSION: Peripheral lymphocyte counts after cervical cancer surgery are important prognostic factors, and management aimed at minimizing immune disturbances after surgery should be assessed, especially in patients with LN metastasis. CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.
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MESH
Adult, Aged, Aged, 80 and over, Female, Humans, Lymphocyte Count, Lymphocytes/immunology/*pathology, Lymphocytes, Tumor-Infiltrating/immunology/*pathology, Middle Aged, Prognosis, Retrospective Studies, Uterine Cervical Neoplasms/*blood/immunology/pathology/*surgery, Young Adult
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Peripheral lymphocyte counts after cervical cancer surgery are important prognostic factors, and management aimed at minimizing immune disturbances after surgery should be assessed.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1016/j.ygyno.2012.05.039.
KCD코드
ICD 03
건강보험코드