Lee, Yoo-Young; Choi, Chel Hun; Sung, Chang Ohk; Do, In-Gu; Hub, Seung Jae; Kim, Ha-Jeong; Kim, Tae-Joong; Lee, Jeong-Won; Bae, Duk-Soo; Kim, Byoung-Gie
Gynecologic oncology
2012Oct ; 127 ( 1 ) :107-13.
PMID : 22710071
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Lee, Yoo-Young -
Choi, Chel Hun -
Sung, Chang Ohk -
Do, In-Gu -
Hub, Seung Jae -
Kim, Ha-Jeong -
Kim, Tae-Joong -
Lee, Jeong-Won -
Bae, Duk-Soo -
Kim, Byoung-Gie -
ABSTRACT
OBJECTIVE: Immune competence is an important prognostic factor in cancer patients. Surgical management of cancer can cause a variety of immunological disturbances, the clinical consequences of which are still unclear. MATERIALS AND
METHODS: Patients with clinically staged cervical carcinoma (IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea from 1994 to 2007 were retrospectively enrolled. We compared peri-operative peripheral lymphocyte counts, tumor-infiltrating lymphocyte scores, and survival in patients with early cervical cancer treated by abdominal type III radical hysterectomy.
RESULTS: The sample included 756 patients. The median follow-up was 58 months with a range of 3-181 months. There was a positive correlation between pre-operative peripheral lymphocyte counts and tumor infiltrating lymphocyte score. Pre-operative peripheral lymphocyte counts decreased significantly after surgery. In multivariate analyses for recurrence, higher pre-operative peripheral lymphocyte counts and recovery of lymphocyte counts (more than 100/muL from the pre-operative level) on post-operative day 3 were independent positive prognostic factors and LN metastasis was negatively associated with post-operative recovery of peripheral lymphocyte counts. CONCLUSION: Peripheral lymphocyte counts after cervical cancer surgery are important prognostic factors, and management aimed at minimizing immune disturbances after surgery should be assessed, especially in patients with LN metastasis. CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.
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MESH
Adult, Aged, Aged, 80 and over, Female, Humans, Lymphocyte Count, Lymphocytes/immunology/*pathology, Lymphocytes, Tumor-Infiltrating/immunology/*pathology, Middle Aged, Prognosis, Retrospective Studies, Uterine Cervical Neoplasms/*blood/immunology/pathology/*surgery, Young Adult
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