Lee, Sung Jong; Yeo, Seung Geun; Park, Dong Choon
International journal of medical sciences
2012NA ; 9 ( 1 ) :103-7.
PMID : 22211097
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Lee, Sung Jong -
Yeo, Seung Geun -
Park, Dong Choon -
ABSTRACT
OBJECTIVE: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.
METHODS: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test) and high-risk HPV tests. Biopsies were taken from some women and their results were compared.
RESULTS: The prevalence of high-risk HPV infection is 24.15%. And the women aged 20-29 years had the highest prevalence (32.3%) compared to 30-70 years (P<0.05). Of the 28,339 women, 1369 (4.83%) had positive PAP test (ASCUS, LSIL, HSIL). Of the 1369 PAP-positive patients, only 16 (1.17%) were negative for HPV test. Of the 1353 patients positive on both tests, 510 (37.7%) had lesions higher than CINII on histology. Of the 1,611 patients who underwent biopsies, 350 underwent the loop electrical excision procedure, with 339 (96%) being positive for HPV test, including 16 with CINI, 48 with CINII/III, 74 with CIS, and 16 with cervical cancer. HPV test had a positive predictive value of 40.7% and a negative predictive value of 100% for higher than CINII. CONCLUSION: Although HPV test has a burden of cost, considering its high negative predictive value, HPV test should be considered for more useful screening test.
keyword
HPV infection; cervical cancer; screening test
MESH
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Biopsy, Female, Humans, Mass Screening, Middle Aged, Papanicolaou Test, Papillomaviridae/*pathogenicity, Papillomavirus Infections/epidemiology/pathology/*virology, Risk Assessment, Uterine Cervical Neoplasms/epidemiology/pathology/*virology, Vaginal Smears/methods
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