Kim, Sina; Shin, Byung-Cheul; Lee, Myeong Soo; Lee, Hyangsook; Ernst, Edzard
Chinese journal of integrative medicine
2011Dec ; 17 ( 12 ) :937-44.
PMID : 22139546
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Kim, Sina -
Shin, Byung-Cheul -
Lee, Myeong Soo -
Lee, Hyangsook -
Ernst, Edzard -
ABSTRACT
OBJECTIVE: Red ginseng (RG, Panax ginseng C.A. Meyer) is one of the widely used herbs for treating type 2 diabetes mellitus (DM). However, no systematic review of the effectiveness of RG for type 2 DM is available. This systematic review aimed to evaluate the current evidence for the effectiveness of RG in patients with type 2 DM.
METHODS: Electronic searches of 14 electronic databases were conducted without language restrictions. All randomized clinical trials (RCTs) with RG as a treatment for type 2 DM were considered for inclusion. Their methodological quality was assessed using the Cochrane criteria.
RESULTS: Four RCTs met our inclusion criteria. Their methodological quality was variable. Three of the RCTs compared the effectiveness of RG with placebo. The meta-analysis of these data failed to favor RG over placebo for fasting plasma glucose (FPG) [n =76, weighted mean difference (WMD): -0.43 mmol/L; 95% confidence interval (CI): -1.16 to 0.30, =0.25] and fasting plasma insulin (FPI) (n =76, WMD: -8.43 pmol/L; 95% CI: -19.54 to 2.68, P =0.14) for 12 weeks of treatment. One RCT compared the effects of RG with no treatment. The results did not suggest favorable effects of RG on FPG, hemoglobin A(1c) (HbA(1c)) or 2-h blood glucose after a meal (PP2h).
CONCLUSIONS: The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition.
Red ginseng; Panax ginseng; type 2 diabetes mellitus; systematic revie; meta-analysis
MESH
Diabetes Mellitus, Type 2/*drug therapy, Humans, Panax/*chemistry, Phytotherapy, Plant Extracts/adverse effects/*therapeutic use, Publication Bias, *Randomized Controlled Trials as Topic, Risk Factors, Treatment Outcome
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