Evaluation of four rapid diagnostic tests for the diagnosis of Plasmodium vivax in Korea.

Kim, Kyung Hee; Jang, Jin Woo; Woo, Mi Kyung; Oh, Jun Seo; Han, Eun Taek; Lee, Won Ja; An, Seong Soo A; Lim, Chae Seung
Tropical medicine & international health : TM & IH
2011Nov ; 16 ( 11 ) :1427-31.
저자 상세정보
Kim, Kyung Hee -
Jang, Jin Woo -
Woo, Mi Kyung -
Oh, Jun Seo -
Han, Eun Taek -
Lee, Won Ja -
An, Seong Soo A -
Lim, Chae Seung -
OBJECTIVE: To evaluate 4 rapid malaria diagnostic kits (RDTs) in Korea: OptiMAL test, SD BIOLINE Malaria Ag P.f/Pan test, Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test.

METHODS: Hundred malaria patients with Plasmodium vivax (P. vivax) and 100 healthy volunteers were recruited. The results from earlier four RDTs were compared with the reference standard, the Giemsa-stained traditional microscopic diagnosis.

RESULTS: Compared with the reference standard, the sensitivity and specificity for Plasmodium vivax were 92.7 and 100% for SD BIOLINE Malaria Ag P.f/Pan; and 94.6% and 100% for OptiMAL; 95.5% and 100% for both Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test. CONCLUSION: The performances of all four malaria RDT kits were acceptable, although Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test gave superior performances with ROK isolates. CI - ??2011 Blackwell Publishing Ltd.
Plasmodium vivax; OptiMAL; CareStart; sensitivity; specificity; Plasmodium vivax; Optimal; CareStart; sensibilit? sp?ificit? Plasmodium vivax; OptiMAL; CareStart; Sensibilidad; Especificidad
Adult, Animals, Diagnostic Tests, Routine/*methods, Humans, Malaria, Vivax/*diagnosis, Plasmodium vivax/*isolation & purification, Predictive Value of Tests, Reagent Kits, Diagnostic/*standards, Republic of Korea, Sensitivity and Specificity, Young Adult

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
All four RDT kits revealed very high sensitivities (range, 92.7?5.5%) and high specificities(range, 100%) for P. vivax. Two new kits, Humasis Malaria P.f/ Pan antigen test and CareStart TM Malaria Pf / Pv Combo test, had a higher sensitivity than other previously developed commercial RDTs, SD BIOLINE Malaria Ag P.f / Pan and OptiMAL, in ROK.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03