Hepatocellular carcinoma with portal vein tumor thrombosis: Improved treatment outcomes with external beam radiation therapy.

Kim, Ji-Yoon; Chung, Su-Mi; Choi, Byung-Ock; Kay, Chul-Seung
Hepatology research : the official journal of the Japan Society of Hepatology
2011Sep ; 41 ( 9 ) :813-24.
저자 상세정보
Kim, Ji-Yoon -
Chung, Su-Mi -
Choi, Byung-Ock -
Kay, Chul-Seung -
ABSTRACT
The treatment of advanced hepatocellular carcinoma (HCC) associated with portal vein tumor thrombosis (PVTT) is very challenging because of HCC's grave prognosis. Despite many efforts to improve the treatment results, patient survival has been limited to several months. In this situation, radiotherapy has been considered as an alternative treatment modality because of the growth of knowledge about the radiotolerance of normal tissue and the advances of radiotherapy techniques such as three dimensional conformal radiotherapy, intensity modulated radiotherapy, stereotactic body radiotherapy and proton therapy. More restoration of the liver function and longer survival of the patients can be achieved by the better response after radiotherapy. However, considering the high risk of intrahepatic advanced tumor or extrahepatic dissemination by PVTT at disease presentation, a combination of radiation therapy and systemic agents will be desirable. Therefore, performing prospective randomized clinical trials is important to assess the benefits of radiotherapy and to develop combination treatment strategies. CI - ??2011 The Japan Society of Hepatology.
hepatocellular carcinoma, portal vein tumorthrombosis, radiotherapy
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
External beam radiotherapy could be considered as an alternative treatment or a combined treatment modality in addition to TACE, HIAC or systemic chemotherapy.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
https://doi.org/10.1111/j.1872-034X.2011.00826.x
KCD코드
ICD 03
건강보험코드