Hepatocellular carcinoma with portal vein tumor thrombosis: Improved treatment outcomes with external beam radiation therapy.

Kim, Ji-Yoon; Chung, Su-Mi; Choi, Byung-Ock; Kay, Chul-Seung
Hepatology research : the official journal of the Japan Society of Hepatology
2011Sep ; 41 ( 9 ) :813-24.
PMID : 21696524
ÀúÀÚ »ó¼¼Á¤º¸
Kim, Ji-Yoon -
Chung, Su-Mi -
Choi, Byung-Ock -
Kay, Chul-Seung -
ABSTRACT
The treatment of advanced hepatocellular carcinoma (HCC) associated with portal vein tumor thrombosis (PVTT) is very challenging because of HCC's grave prognosis. Despite many efforts to improve the treatment results, patient survival has been limited to several months. In this situation, radiotherapy has been considered as an alternative treatment modality because of the growth of knowledge about the radiotolerance of normal tissue and the advances of radiotherapy techniques such as three dimensional conformal radiotherapy, intensity modulated radiotherapy, stereotactic body radiotherapy and proton therapy. More restoration of the liver function and longer survival of the patients can be achieved by the better response after radiotherapy. However, considering the high risk of intrahepatic advanced tumor or extrahepatic dissemination by PVTT at disease presentation, a combination of radiation therapy and systemic agents will be desirable. Therefore, performing prospective randomized clinical trials is important to assess the benefits of radiotherapy and to develop combination treatment strategies. CI - ??2011 The Japan Society of Hepatology.
hepatocellular carcinoma, portal vein tumorthrombosis, radiotherapy
¸µÅ©

ÁÖÁ¦ÄÚµå
ÁÖÁ¦¸í(Target field)
¿¬±¸´ë»ó(Population)
¿¬±¸Âü¿©(Sample size)
´ë»ó¼ºº°(Gender)
Áúº´Æ¯¼º(Condition Category)
¿¬±¸È¯°æ(Setting)
¿¬±¸¼³°è(Study Design)
¿¬±¸±â°£(Period)
ÁßÀç¹æ¹ý(Intervention Type)
ÁßÀç¸íĪ(Intervention Name)
Å°¿öµå(Keyword)
À¯È¿¼º°á°ú(Recomendation)
External beam radiotherapy could be considered as an alternative treatment or a combined treatment modality in addition to TACE, HIAC or systemic chemotherapy.
¿¬±¸ºñÁö¿ø(Fund Source)
±Ù°Å¼öÁØÆò°¡(Evidence Hierarchy)
ÃâÆdz⵵(Year)
Âü¿©ÀúÀÚ¼ö(Authors)
´ëÇ¥ÀúÀÚ
DOI
https://doi.org/10.1111/j.1872-034X.2011.00826.x
KCDÄÚµå
ICD 03
°Ç°­º¸ÇèÄÚµå