Hahn, Suk Jae; Oh, Jin Young; Kim, Jeung Sook; Kim, Do Yeun
International journal of clinical oncology
2011Dec ; 16 ( 6 ) :732-6.
PMID : 21455627
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Hahn, Suk Jae -
Oh, Jin Young -
Kim, Jeung Sook -
Kim, Do Yeun -
ABSTRACT
Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.
Aged; Anticoagulants/therapeutic use; Aorta/*pathology; Carcinoma, Non-Small-Cell Lung/diagnosis/*drug therapy/physiopathology; Cisplatin/*adverse effects/therapeutic use; Heparin/therapeutic use; Humans; Lung Neoplasms/diagnosis/*drug therapy/physiopathology; Male; Pleural Effusion, Malignant/drug therapy; Thrombosis/*chemically induced/drug therapy/pathology; Warfarin/therapeutic use
MESH
Aged, Anticoagulants/therapeutic use, Aorta/*pathology, Carcinoma, Non-Small-Cell Lung/diagnosis/*drug therapy/physiopathology, Cisplatin/*adverse effects/therapeutic use, Heparin/therapeutic use, Humans, Lung Neoplasms/diagnosis/*drug therapy/physiopathology, Male, Pleural Effusion, Malignant/drug therapy, Thrombosis/*chemically induced/drug therapy/pathology, Warfarin/therapeutic use
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