Comparison between surgery and radiofrequency ablation for stage I non-small cell lung cancer.

Kim, So Ri; Han, Hyo Jin; Park, Seoung Ju; Min, Kyung Hoon; Lee, Min Hee; Chung, Chi Ryang; Kim, Min Ho; Jin, Gong Yong; Lee, Yong Chul
European journal of radiology
2012Feb ; 81 ( 2 ) :395-9.
저자 상세정보
Kim, So Ri -
Han, Hyo Jin -
Park, Seoung Ju -
Min, Kyung Hoon -
Lee, Min Hee -
Chung, Chi Ryang -
Kim, Min Ho -
Jin, Gong Yong -
Lee, Yong Chul -
ABSTRACT
Surgical resection remains as the treatment of choice for non-small cell lung cancer (NSCLC) and provides the best opportunity for cure and long-term survival. Minimally invasive percutaneous ablative therapies, such as radiofrequency ablation (RFA) for treating lung cancers, are currently being studied as treatment alternatives. But, to date, there is little information on comparison of therapeutic effects between surgery and RFA in patients with early stage lung malignancy. We aimed to investigate the clinical significance of RFA as an alternative curative modality for the early stage lung cancer through analyzing the long-term mortality of both treatment groups; surgery vs. RFA. Twenty-two patients of stage I NSCLC were included for this comparative analysis. To minimize confounding effects, we conducted a matching process. In which patients of RFA group (n = 8) were matched with patients of surgery group (n = 14) on the following variables; gender, age (짹 3 years), tumor node metastasis stage, and calendar year of surgery or RFA (짹 2 years). The mean survival duration of RFA group and surgery group were 33.18 짹 7.90 and 45.49 짹 7.21, respectively (months, p = 0.297). Log-rank analysis showed that there was no significant difference in overall survival (p = 0.054) between two groups. These results have shown that RFA can offer the survival comparable to that by surgery to stage I NSCLC patients, especially to the patients impossible for the surgery. This study provides an evidence for the use of RFA as a treatment alternative with low procedural morbidity for inoperable early-stage NSCLC patients. CI - Copyright ??2011 Elsevier Ireland Ltd. All rights reserved.
Aged, Carcinoma, Non-Small-Cell Lung/*surgery, *Catheter Ablation, Female, Humans, Lung Neoplasms/*surgery, Male, Pneumonectomy/*methods, Surgery, Computer-Assisted/*methods, Tomography, X-Ray Computed/*methods, Treatment Outcome
MESH
Aged, Carcinoma, Non-Small-Cell Lung/*surgery, *Catheter Ablation, Female, Humans, Lung Neoplasms/*surgery, Male, Pneumonectomy/*methods, Surgery, Computer-Assisted/*methods, Tomography, X-Ray Computed/*methods, Treatment Outcome
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Our comparative data show that minimally invasive strategy such as RFA can be considered as an alternative option for stage I lung cancer patients who are not able to receive a surgery.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1016/j.ejrad.2010.12.091.
KCD코드
ICD 03
건강보험코드