Lee, S A; Lee, W J; Kim, E H; Yu, J H; Jung, C H; Koh, E H; Kim, M-S; Park, J-Y; Lee, K-U
Diabetic medicine : a journal of the British Diabetic Association
2011Mar ; 28 ( 3 ) :319-24.
PMID : 21309840
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Lee, S A -
Lee, W J -
Kim, E H -
Yu, J H -
Jung, C H -
Koh, E H -
Kim, M-S -
Park, J-Y -
Lee, K-U -
ABSTRACT
AIMS: To investigate the rate of progression to insulin deficiency in Korean patients with Type 2 diabetes mellitus positive for anti-GAD antibody (GADA) and to determine the factors related to progression to insulin deficiency.
METHODS: We retrospectively analysed data on 87 GADA-positive and 87 age- and sex-matched GADA-negative patients with Type 2 diabetes. GADA-positive patients were further subclassified into high-titre (??250 WHO units/ml) (n = 24) and low-titre (< 250 WHO units/ml) (n = 63) subgroups. Cox proportional hazard analysis was used to identify factors associated with progression to insulin deficiency.
RESULTS: Over a period of 6 years, two of 87 (2.3%) GADA-negative and 37 of 87 (42.5%) GADA-positive patients had progressed to insulin deficiency. The rate of progression to insulin deficiency was higher in the high-titre than in the low-titre subgroup (75.0 vs. 30.2%). Multivariate analysis in GADA-positive patients showed that high-titre GADA and low BMI at diagnosis were independent factors significantly related to progression to insulin deficiency.
CONCLUSIONS: The presence of GADA predicted the progression to insulin deficiency in Korean patients with Type 2 diabetes. In GADA-positive patients, high-titre GADA and low BMI were associated with this progression. CI - ??2011 The Authors. Diabetic Medicine ??2011 Diabetes UK.
anti-GAD antibody, C-peptide, insulin deficiency, Type 2 diabetes mellitus
MESH
*Asian Continental Ancestry Group, Autoantibodies/*analysis, Diabetes Mellitus, Type 1/blood/*immunology/physiopathology, Diabetes Mellitus, Type 2/blood/*immunology/physiopathology, Disease Progression, Female, Humans, Islets of Langerhans/*immunology, Male, Middle Aged, Proportional Hazards Models, Retrospective Studies
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