Jung, Sun Young; Yoo, Su Jin; Shin, Ji Young; Park, Ji Won; Lee, Jeong Eun; Park, Hee Sun; Kim, Ju Ock; Kim, Sun Young
Zhongguo fei ai za zhi = Chinese journal of lung cancer
2011Jan ; 14 ( 1 ) :33-8.
PMID : 21219829
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Jung, Sun Young -
Yoo, Su Jin -
Shin, Ji Young -
Park, Ji Won -
Lee, Jeong Eun -
Park, Hee Sun -
Kim, Ju Ock -
Kim, Sun Young -
ABSTRACT
BACKGROUND AND OBJECTIVE: Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancer (NSCLC) in progression after first-line chemotherapy. We evaluated the activity and feasibility of pemetrexed in previously treated NSCLC.
METHODS: Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March 2009. The patients had relapsed or progressed after prior chemotherapy treatment. Pemetrexed (500 mg/m²) was administered intravenously once every 3 weeks after progression to prior chemotherapy. The tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of chemotherapy.
RESULTS: A total 61 patients were eligible for analysis. Performance status of them (100%) was over 2. The response rate and disease control rate were 14.7% and 37.7% respectively. Non-squamous cell carcinoma histology was significantly associated with a superior response rate (P=0.045) and disease control rate (P=0.008). The median survival time and the median progression free survival (PFS) time were 6.11 months and 2.17 months, respectively. Comparing the efficacy of pemetrexed in these two settings [second-line versus (12/61) more than third (49/61)], there was no significant difference in regard to median survival (11.18 months vs 11.46 months, P=0.922,5), but PFS was more longer in third- or further-line groups than second-line group (1.39 months vs 2.25 months, P=0.015,3).
CONCLUSIONS: Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.
Pemetrexed; Lung neoplasms; Poor performance
MESH
Aged, Aged, 80 and over, Antineoplastic Agents/*therapeutic use, Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology, Female, Glutamates/*therapeutic use, Guanine/*analogs & derivatives/therapeutic use, Humans, Lung Neoplasms/*drug therapy/pathology, Male, Middle Aged, Pemetrexed, Retrospective Studies, Treatment Outcome
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