Kim, Eun Sook; Kwon, Hyuk Sang; Ahn, Chul Woo; Lim, Dong Jun; Shin, Jeong Ah; Lee, Seung Hwan; Cho, Jae Hyoung; Yoon, Kun Ho; Kang, Moo Il; Cha, Bong Yun; Son, Ho Young
Journal of diabetes and its complications
2011Sep ; 25 ( 5 ) :309-13.
PMID : 21130003
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Kim, Eun Sook -
Kwon, Hyuk Sang -
Ahn, Chul Woo -
Lim, Dong Jun -
Shin, Jeong Ah -
Lee, Seung Hwan -
Cho, Jae Hyoung -
Yoon, Kun Ho -
Kang, Moo Il -
Cha, Bong Yun -
Son, Ho Young -
ABSTRACT
AIMS: To determine the relationship between serum uric acid, metabolic syndrome (MetS), and albuminuria in type 2 diabetic patients.
METHODS: A total of 504 Korean patients with type 2 diabetes aged 57.3 years were retrospectively evaluated for clinical histories, anthropometric measurements, and biochemical studies. Urinary albumin excretion (UAE) was measured by a 24-h urine collection.
RESULTS: Prevalence of MetS increased according to the quartiles of uric acid levels (??.7, 3.8 to 4.5, 4.6 to 5.5, and >5.5 mg/dl; 52.1%, 52.1%, 57.5%, and 71.6%, respectively, P<.001). Individual components of MetS (abdominal obesity, hypertriglyceridemia, low HDL-cholesterol, high blood pressure) were also significantly associated with the highest quintile of uric acid levels. Serum uric acid levels had significantly increased risk of albuminuria [odds ratio (OR) 1.425, 95% confidence interval (CI) 1.085-1.873] after adjusting for age, gender, and conventional risk factors. Uric acid level remains a significant predictor for abnormal albuminuria after adjusting for MetS presence as well as the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) (OR 1.414, 95% CI 1.071-1.868). CONCLUSION: An elevated uric acid level was significantly associated with MetS and was an independent predictor of albuminuria after adjusting for conventional risk factors and MetS. Regular measurements of uric acid level could give information for predicting the presence of MetS and albuminuria in Korean type 2 diabetic patients. CI - Copyright ??2011 Elsevier Inc. All rights reserved.
Uric acidAlbuminuria; Metabolic syndrome; Type 2 diabetes mellitus
MESH
Adult, Aged, Albuminuria/complications/*epidemiology/etiology, Angiotensin Receptor Antagonists/adverse effects/therapeutic use, Angiotensin-Converting Enzyme Inhibitors/adverse effects/therapeutic use, Antihypertensive Agents/adverse effects/therapeutic use, Diabetes Mellitus, Type 2/*blood/complications/*urine, Female, Humans, Hypertension/drug therapy/etiology, Male, Metabolic Syndrome X/complications/*epidemiology/physiopathology, Middle Aged, Models, Biological, Prevalence, Renal Insufficiency, Chronic/complications/epidemiology/physiopathology, Republic of Korea/epidemiology, Retrospective Studies, Risk Factors, Severity of Illness Index, Uric Acid/*blood
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