Diabetic retinopathy is associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus.

Son, Jang-Won; Jang, Eun-Hee; Kim, Mee-Kyoung; Kim, In Tae; Roh, Young Jung; Baek, Ki-Hyun; Song, Ki-Ho; Yoon, Kun-Ho; Cha, Bong-Yun; Lee, Kwang-Woo; Son, Ho-Young; Kwon, Hyuk-Sang
Diabetes research and clinical practice
2011Feb ; 91 ( 2 ) :253-9.
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Son, Jang-Won -
Jang, Eun-Hee -
Kim, Mee-Kyoung -
Kim, In Tae -
Roh, Young Jung -
Baek, Ki-Hyun -
Song, Ki-Ho -
Yoon, Kun-Ho -
Cha, Bong-Yun -
Lee, Kwang-Woo -
Son, Ho-Young -
Kwon, Hyuk-Sang -
ABSTRACT
AIMS: We aimed to evaluate the association between diabetic microangiopathy and subclinical atherosclerosis as a marker of cardiovascular disease (CVD) risk in patients with newly diagnosed type 2 diabetes.

METHODS: A total of 142 newly diagnosed type 2 diabetics who were free from CVD underwent evaluation of diabetic microangiopathy. Subclinical atherosclerosis was assessed by measuring carotid intima-media thickness (IMT), and the 10-year absolute risk of CVD was estimated using the UK Prospective Diabetes Study (UKPDS) Risk Engine.

RESULTS: Subclinical atherosclerosis was found in 27 subjects (19.0%). The rates of hypertension and diabetic retinopathy were significantly higher among patients with subclinical atherosclerosis. The UKPDS 10-year risk for CVD was significantly increased in subjects with subclinical atherosclerosis. Old age, hypertension and the presence of diabetic retinopathy showed a significant association to subclinical atherosclerosis after further adjustments for gender, body mass index, smoking status, HbA1c, HDL cholesterol, LDL cholesterol and the presence of diabetic nephropathy.

CONCLUSIONS: This study shows that diabetic retinopathy is an independent risk marker for subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. We suggest that a diagnosis of diabetic retinopathy may warrant a more careful cardiovascular assessment even in the early stages of diabetes. CI - Copyright ??2010 Elsevier Ireland Ltd. All rights reserved.
Diabetic retinopathy; Carotid intima-media thickness; Atherosclerosis
MESH
Adult, Aged, Atherosclerosis/*epidemiology/etiology, Diabetes Mellitus, Type 2/diagnosis/*epidemiology/physiopathology, Diabetic Retinopathy/*epidemiology/physiopathology, Female, Humans, Male, Middle Aged, Risk Factors, Tunica Intima/pathology, Tunica Media/pathology
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Diabetic retinopathy is an independent risk marker for subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes.
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DOI
10.1016/j.diabres.2010.11.005
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ICD 03
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