Park, Sang Gyu; Park, Ho Seon; Jeong, In-Kyong; Cho, Young Min; Lee, Hong Kyu; Kang, Young-Sun; Kim, Sunghoon; Park, Kyong Soo
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
2010Jun ; 15 ( 4 ) :358-66.
PMID : 20429837
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Park, Sang Gyu -
Park, Ho Seon -
Jeong, In-Kyong -
Cho, Young Min -
Lee, Hong Kyu -
Kang, Young-Sun -
Kim, Sunghoon -
Park, Kyong Soo -
ABSTRACT
OBJECTIVES: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM.
METHODS: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM.
RESULTS: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p <0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. CONCLUSION: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.
Pancreas, autoantibody, antisynthetase syndrome, autoimmune disease, ELISA
MESH
Adult, Amino Acyl-tRNA Synthetases/*immunology, Autoantibodies/analysis/*blood, Biomarkers/analysis/blood, Diabetes Mellitus, Type 1/*diagnosis/immunology, Female, Glutamate Decarboxylase/immunology, Humans, Male, Middle Aged, Pancreas/immunology, Receptor-Like Protein Tyrosine Phosphatases, Class 8/immunology
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