Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition.

Baek, Jung Hwan; Kim, Yoon Suk; Lee, Ducky; Huh, Jung Yin; Lee, Jeong Hyun
AJR. American journal of roentgenology
2010Apr ; 194 ( 4 ) :1137-42.
저자 상세정보
Baek, Jung Hwan -
Kim, Yoon Suk -
Lee, Ducky -
Huh, Jung Yin -
Lee, Jeong Hyun -
ABSTRACT
OBJECTIVE: The purpose of this study was to evaluate the efficacy of radiofrequency ablation of benign predominantly solid thyroid nodules by comparing the findings in treatment and control groups. SUBJECTS AND

METHODS: Thirty patients with normal thyroid function, each with a benign predominantly (> 50%) solid thyroid nodule causing pressure symptoms or cosmetic problems, were assigned to a control group (n = 15) or to a group undergoing a single session of radiofrequency ablation (n = 15). Thyroid nodule volume, thyroid function, pressure symptoms, and cosmetic concerns were evaluated before treatment and during follow-up. Sonographically guided radiofrequency ablation was performed with an internally cooled electrode (1-cm active tip) with an output power of 30-80 W.

RESULTS: The control group had no resolution of symptoms or cosmetic problems. The mean nodule volume increased slightly after 6 months but without statistical significance (p = 0.46). In the radiofrequency ablation group, the mean symptom score (p = 0.001) and cosmetic grade (p = 0.001) improved significantly. Mean nodule volume decreased significantly from 7.5 +/- 4.9 mL (range, 1.7-20.0 mL) to 1.3 +/- 0.8 mL (range, 0.2-2.6 mL) 6 months after radiofrequency ablation (p = 0.001). There were no major complications of ablation. CONCLUSION: This study confirmed that radiofrequency ablation is effective for reducing nodule volume and relieving nodule-related clinical problems and that an effect due to spontaneous nodule reduction can be excluded owing to the results of the comparison with a similar control group.
intervention, radiofrequency ablation, thyroid, thyroid nodule
MESH
Adult, Aged, Biopsy, Case-Control Studies, *Catheter Ablation, Esthetics, Female, Humans, Male, Middle Aged, Prospective Studies, Statistics, Nonparametric, Thyroid Function Tests, Thyroid Nodule/radionuclide imaging/*surgery/ultrasonography, Treatment Outcome, *Ultrasonography, Interventional
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
In the radiofrequency ablation group, the mean symptom score (p = 0.001) and cosmetic grade (p = 0.001) improved significantly. Mean nodule volume decreased significantly from 7.5 +/- 4.9 mL (range, 1.7-20.0 mL) to 1.3 +/- 0.8 mL (range, 0.2-2.6 mL) 6 months after radiofrequency ablation (p = 0.001).
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.2214/AJR.09.3372.
KCD코드
ICD 03
건강보험코드