Lee, J-M; Kim, J-H; Son, H-S; Hong, E-G; Yu, J-M; Han, K-A; Min, K-W; Chang, S-A
The Journal of international medical research
2010Jan ; 38 ( 1 ) :234-41.
PMID : 20233535
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Lee, J-M -
Kim, J-H -
Son, H-S -
Hong, E-G -
Yu, J-M -
Han, K-A -
Min, K-W -
Chang, S-A -
ABSTRACT
Evaluating increasing circulating adiponectin levels is becoming an important strategy in the prevention of diabetes mellitus and cardiovascular events. This study was designed to investigate the effect of the angiotensin II receptor blocker valsartan on blood adiponectin levels and insulin sensitivity in patients with type 2 diabetes and mild-to-moderate hypertension. A total of 91 Korean patients were treated with 80 mg/day valsartan for 4 weeks followed by 160 mg/day for a further 8 weeks. Blood pressure, adiponectin levels and metabolic parameters were measured before and after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an insulin sensitivity index. Valsartan significantly decreased mean blood pressure and increased circulating adiponectin levels. There were no differences in metabolic parameters, including HOMA-IR, glycosylated haemoglobin and lipid levels before and after treatment. These results indicated that valsartan increases circulating adiponectin levels, but does not change insulin sensitivity in patients with type 2 diabetes and mild-to-moderate hypertension.
TYPE 2 DIABETES MELLITUS; HYPERTENSION; VALSARTAN; ANGIOTENSIN II RECEPTOR BLOCKER; ADIPONECTIN; INSULIN SENSITIVITY
MESH
Adiponectin/*blood, Angiotensin II Type 1 Receptor Blockers/*pharmacology, Blood Glucose/metabolism, Body Mass Index, Diabetes Mellitus, Type 2/blood/*drug therapy/physiopathology, Female, Follow-Up Studies, Homeostasis, Humans, Hypertension/blood/*drug therapy/physiopathology, *Insulin Resistance, Male, Middle Aged, Tetrazoles/*pharmacology, Treatment Outcome, Valine/*analogs & derivatives/pharmacology, Valsartan
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