Kim, Insub; Lee, Junhee; Hong, Hyun Joo; Jung, Eun Sun; Ku, Yun Hyi; Jeong, In Kyong; Cho, Young Min; So, Insuk; Park, Kyong Soo; Mook-Jung, Inhee
Journal of Alzheimer's disease : JAD
2010NA ; 19 ( 4 ) :1371-6.
PMID : 20061608
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Kim, Insub -
Lee, Junhee -
Hong, Hyun Joo -
Jung, Eun Sun -
Ku, Yun Hyi -
Jeong, In Kyong -
Cho, Young Min -
So, Insuk -
Park, Kyong Soo -
Mook-Jung, Inhee -
ABSTRACT
Increasing evidence suggests that type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer's disease (AD). To examine the relationship between T2DM and AD, autoantibodies against amyloid-Abeta were measured in the serum of T2DM patients and age-matched controls. Levels of Abeta autoantibody were measured by ELISA in serum samples of T2DM patients (n=92) and age-matched control group (n=106). Abeta autoantibody levels were increased in T2DM compared with age-matched controls by 45.4 +/- 8.1% (p< 0.001). Females had higher Abeta autoantibody levels than males in both T2DM and control group. Abeta autoantibody levels in the T2DM group were positively correlated with the levels of cholesterol (p=0.011), low density lipoprotein cholesterol (p=0.020), and triglycerides (p=0.039). In conclusion, the level of Abeta autoantibody is dramatically elevated in patient serum of T2DM, and, as such, might be used as a possible biomarker for T2DM.
A¥â autoantibody, Alzheimer's disease, biomarker, cholesterol, type 2 diabetes mellitus
MESH
Alzheimer Disease/*blood/*epidemiology, Amyloid beta-Peptides/*blood/*immunology, Autoantibodies/*blood/*immunology, Diabetes Mellitus, Type 2/*blood/*epidemiology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G/blood, Male, Middle Aged
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