Cho, Su-Hee; Go, Se-Il; Lee, Gyeong-Won; Kang, Jung Hun; Kim, Hoon-Gu; Kim, Seok Hyun; Cho, Yu Ji; Jeong, Yi Yeong; Kim, Ho-Cheol; Lee, Jong Duk; Hwang, Young Sil
Lung cancer (Amsterdam, Netherlands)
2010Jul ; 69 ( 1 ) :94-8.
PMID : 19796840
ÀúÀÚ »ó¼¼Á¤º¸
Cho, Su-Hee -
Go, Se-Il -
Lee, Gyeong-Won -
Kang, Jung Hun -
Kim, Hoon-Gu -
Kim, Seok Hyun -
Cho, Yu Ji -
Jeong, Yi Yeong -
Kim, Ho-Cheol -
Lee, Jong Duk -
Hwang, Young Sil -
ABSTRACT
PURPOSE: We investigated the efficacy and toxicity of a biweekly schedule of docetaxel and cisplatin in patients with metastatic non-small cell lung cancer (NSCLC).
METHODS: In this study, 48 patients with previously untreated metastatic NSCLC were given combination chemotherapy consisting of docetaxel 40 mg/m(2) and cisplatin 40 mg/m(2); both drugs were given biweekly, on days 1 and 15, every 4 weeks.
RESULTS: A partial response and stable disease were observed in 25 patients (52.1%, 95% CI: 38.7-66.9%) and ten patients (20.8%), respectively. The overall median survival was 14.0 months (95% CI: 7.10-20.9 months). There was no treatment-related mortality. The major toxicity was grade 2 asthenia (35.4%). Grade 4 neutropenia was observed in two patients (4.2%), as was grade 3 infection (4.2%).
CONCLUSIONS: As a front-line chemotherapy in an outpatient setting for patients with metastatic NSCLC, the biweekly schedule of docetaxel and cisplatin showed effective antitumor activity with a marked reduction in hematologic toxicity, comparable to the results of previous studies using 3-week or weekly schedules. Further randomized studies are needed before this can be accepted as a standard schedule. CI - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
na
MESH
Adult, Aged, *Antineoplastic Combined Chemotherapy Protocols, Asthenia/etiology, Carcinoma, Non-Small-Cell Lung/*drug therapy/mortality/pathology/physiopathology, Cisplatin/*administration & dosage/adverse effects, Female, Humans, Infection/etiology, Lung Neoplasms/*drug therapy/mortality/pathology/physiopathology, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Neutropenia/etiology, Survival Analysis, Taxoids/*administration & dosage/adverse effects
¸µÅ©