Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience.

Kim, Young-Sun; Rhim, Hyunchul; Tae, Kyung; Park, Dong Woo; Kim, Sung Tae
Thyroid : official journal of the American Thyroid Association
2006Apr ; 16 ( 4 ) :361-7.
저자 상세정보
Kim, Young-Sun -
Rhim, Hyunchul -
Tae, Kyung -
Park, Dong Woo -
Kim, Sung Tae -
ABSTRACT
CONTEXT AND OBJECTIVE: To evaluate the efficacy and safety of ultrasound (US)-guided percutaneous radiofrequency (RF) ablation for benign cold thyroid nodules as a nonsurgical therapeutic modality. DESIGN, INTERVENTION, AND PATIENTS: A total of 35 benign cold thyroid nodules in 30 euthyroid patients (M:F = 2:28; mean age 39.1 years) underwent percutaneous RF ablation with a 1-cm-internally cooled electrode. Seventy-seven percent (23/30) of patients required conscious sedation for discomfort. We evaluated the tumor size, cystic component, vascularity (by color Doppler US), and the severity of mass-related symptoms before treatment. We assessed the therapeutic efficacy and safety of RF ablation by clinical and US follow-up (median 6.4 months). MAIN OUTCOME AND

RESULTS: The volume of the tumors before ablation had a range of 0.6-28.2 mL (mean, 6.3 mL). The residual volume was 53.5% +/- 26.5% of original at 1.1-2.9 months (n = 32), 36.2% +/- 27.4% at 3.0-5.9 months (n = 20), 30.7% +/- 25.0% at 6.0-8.9 months (n = 15), and 11.8% +/- 10.9% at 9.0-18.5 months (n = 13). Mixed/mainly cystic tumors showed a significantly better response than mainly solid tumors (p < 0.05). Difference in vascularity did not affect the treatment response. Thyroid function after the procedure was maintained as normal in all patients. Eighty-eight percent of the patients reported an improvement of their symptoms. There was no major complication other than vocal cord palsy in one patient (3.3%). CONCLUSION: RF ablation may be an effective and safe nonsurgical technique to treat benign cold thyroid nodules.
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MESH
Adolescent, Adult, *Catheter Ablation/adverse effects, Female, Humans, Male, Middle Aged, Thyroid Nodule/pathology/*therapy
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Mixed/mainly cystic tumors showed a significantly better response than mainly solid tumors (p < 0.05). Difference in vascularity did not affect the treatment response. Thyroid function after the procedure was maintained as normal in all patients. Eighty-eight percent of the patients reported an improvement of their symptoms.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
https://doi.org/10.1089/thy.2006.16.361
KCD코드
ICD 03
건강보험코드