Chung, Hyun Hoon; Kim, Seok-Ki; Kim, Tae Hyun; Lee, Sun; Kang, Keon Wook; Kim, Joo-Young; Park, Sang-Yoon
Gynecologic oncology
2006Oct ; 103 ( 1 ) :165-70.
PMID : 16574205
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Chung, Hyun Hoon -
Kim, Seok-Ki -
Kim, Tae Hyun -
Lee, Sun -
Kang, Keon Wook -
Kim, Joo-Young -
Park, Sang-Yoon -
ABSTRACT
OBJECTIVES: To evaluate the ability of whole-body 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) scan to detect recurrent cervical cancer in women during follow-up after definitive treatment.
METHODS: We retrospectively reviewed the whole-body FDG-PET scan of the women who had reached complete response after primary treatment for detection of recurrent cervical cancer between September 1, 2001 and October 31, 2004.
RESULTS: One hundred twenty-one consecutive patients were registered for the current study and seventy-six women were diagnosed as recurrence, twenty of which were asymptomatic. The FDG-PET scan detected 73 (96.1%) patients among 76 patients with recurrent disease and discriminated 38 (84.4%) patients among 45 patients without recurrence. The sensitivity, specificity and accuracy of the FDG-PET scan in assessment of recurrence among patients with cervical cancer were 96.1%, 84.4% and 91.7% respectively. Sixteen patients with no evidence of distant metastasis on FDG-PET scan received pelvic exenteration; complete response was achieved in 6 (37.5%) patients, and all are alive with no evidence of disease. The FDG-PET scan detected FDG-avid lesions in 17 (85.0%) of the 20 asymptomatic patients with recurrent disease, and 8 (40.0%) patients received therapy with curative intent; complete response was achieved in five (25.0%) patients and all are alive with no evidence of disease. Three-year overall survival of this study was 85.6%.
CONCLUSIONS: The whole-body FDG-PET scan is a sensitive post-therapy surveillance modality for detection of recurrent cervical cancer even in asymptomatic patients and aids in deciding treatment plans and, eventually, may have favorable impact on prognosis and survival.
FDG-PET, Surveillance, Recurrent Cervical cancer
MESH
Adult, Aged, Aged, 80 and over, Female, *Fluorodeoxyglucose F18, Humans, Middle Aged, Neoplasm Recurrence, Local/pathology/*radionuclide imaging, Neoplasm Staging, Palliative Care, Pelvic Exenteration, Positron-Emission Tomography/methods, Prognosis, *Radiopharmaceuticals, Retrospective Studies, Salvage Therapy, Sensitivity and Specificity, Uterine Cervical Neoplasms/pathology/*radionuclide imaging/therapy
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